Focusing of the CSF

Classical electrophoresis of CSF has largely been abandoned. In physiological conditions, in comparison with serum, the expression of prealbumin, /3-globulin, 

Classical electrophoresis is not suitable for the detection of intrathecal synthesis of immunoglobulins. 

An increased IgA index is found in aseptic meningitis in 40% of cases and in herpes encephalitis in almost 100% of cases as a result of virus-specific IgA antibody production. In neuromberculosis, an increased IgA index is often accompanied by normal IgC and IgM indices (LI). 

Infection in the Distant Past with a Persisting Anamnestic Immune Response. There are, for example, TPHA antibodies in neurosyphilis (K6, LI, L3). 

Humoral Immune Response in Chronic Inflammatory Processes. The specificity of the diagnostically relevant intrathecal antibodies depends on the underlying cause of the disorder. In the case of chronic infective processes, the antibodies are exclusively targeted against the causative organism (F5). Increased IgC levels are found in about 30% of patients with chronic meningitis or encephalitis from various causes, such as bacteria, virus and protozoa, and in diseases like polyradiculitis, sarcoidosis, and chronic myelopathy (LI). 

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D2. Delmotte, R, and Gonsette, R., Biochemical findings in multiple sclerosis. IV. Isoelectric focusing of the CSF gamma globulins in multiple sclerosis (262 cases) and other neurological diseases (272 Cases). J. Neurol. 215, 27-37 (1977). 

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