Focal embolic ischemia model

Zhang RL, Chopp M, Zhang ZG, Jiang Q, Ewing JR (1997) A rat model of focal embolic cerebral ischemia. Brain Res 766 83-92... 

The effect of hypothermia in combination with thrombolytics has also been evaluated in only a few experimental studies. Meden et al. (11) studied differences in thrombolytic effectiveness in a rat embolic stroke model. In this study, 2 h of intraischemic hypothermia was administered with or without thrombolytic therapy. Thrombolysis was initiated at 2 h after ischemia onset. The investigators found that both hypothermia and thrombolysis significantly reduced infarct volume, but they could not demonstrate any added benefit of thrombolysis over hypothermia alone. A recent study by Wang et al. (12) used a focal embolic brain ischemia model to study the effects of minocycline, an antiinflammatory agent, alone or in combination with mild hypothermia (34—35°C started 1 h after embolization, 2-h duration). The results showed that both minocycline and the hypothermia-minocycline combination reduced infarct volume significantly, but no additive effect was observed. 

Noor, R., Wang, C.X., and Shuaib, A. (2003) Effects of hyperthermia on infarct volume in focal embolic model of cerebral ischemia in rats. Neurosci. Lett., 349 130-132. 

Laminin fAnimal models of HD [55], MDMA injury [76], transient global ischemia [77], brain fet embolism [78], embolic focal cerebral ischemia [79], transient focal cerebral ischemia [80], cerebral ischemia [81], subarachnoid hemorrhage [82], cortical spreading depression [59], aging, and AD [83]... 

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