Fluticasone propionate ointment

The formulation is spread manually or with an applicator. On evaporation of the solvents including water over a period of 20-30 minutes, a continuous medicated adherent film of about 

05- to 0.15-mm (average 0.08 mm) thickness is formed. After 18-24 hours or another desirable time span, the film is removed with water or is peeled. 

Melt microcrystalline wax, hard paraffin, and sorbitan sesquioleate in a fat-melting vessel at 70°-75°C while mixing. Add liquid paraffin and mix well. 

Transfer the mixture in step 1 to the manufacturing vessel through stainless steel filter. Mix and homogenize for 10 minutes under vacuum at 0.5 bar. Cool the mixture to 40° f5°C. 

Disperse fluticasone propionate in propylene glycol, mix, and homogenize at a temperature of 40° 5°C. 

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Fluticasone propionate is administered by nasal spray in the prophylaxis and treatment of allergic rhinitis, but is applied topically in the treatment of various skin disorders (as creams and ointments). 

Fluticasone ointment 0.005% contains fluticasone propionate [(6(alpha),ll(beta),16(alpha),17(alpha))-6,9,-difluoro-ll-hydroxy-16-metliyl-3-oxo-17-(l-oxopropoxy)androsta-l, 4-diene-17-carbothioic acid, S-fluoromethyl ester], a synthetic fluorinated corticosteroid, for topical dermatologic use. The topical corticosteroids constitute a class of pri-... 

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