Fluticasone ointment

Fluticasone ointment 0.005% contains fluticasone propionate [(6(alpha),ll(beta),16(alpha),17(alpha))-6,9,-difluoro-ll-hydroxy-16-metliyl-3-oxo-17-(l-oxopropoxy)androsta-l, 4-diene-17-carbothioic acid, S-fluoromethyl ester], a synthetic fluorinated corticosteroid, for topical dermatologic use. The topical corticosteroids constitute a class of pri- 

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Fluticasone propionate is administered by nasal spray in the prophylaxis and treatment of allergic rhinitis, but is applied topically in the treatment of various skin disorders (as creams and ointments). 

Transfer the drug mixture from step 3 into the manufacturing vessel from step 2 while mixing. Mix and homogenize for 10 minutes under vacuum at 0.5 bar to obtain uniform homogeneous ointment to contain label amount of fluticasone propionate per gram. 

Fluticasone, a topical corticosteroid with antiinflammatory properties (0.05% cream, 0.005% ointment), is used in the relief of inflammation and pruritis of corticosteroid-responsive dermatoses. 

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