Flurbiprofen sodium

CjHjNaO, 113-24-6) see Flurbiprofen sodium salicylate see under salicylic acid sodium salt sodium 3-sulfobenzoate... 

Eideriy Age appears to increase the possibility of adverse reactions to NSAIDs. The risk of serious ulcer disease is increased this risk appears to increase with dose. Ketorolac is cleared more slowly by the elderly use caution and reduce dosage. Pregnancy Category B (ketoprofen, naproxen, naproxen sodium, flurbiprofen, diclofenac, fenoprofen, ibuprofen, indomethacin, meclofenamate, sulindac). 

Fluoro biphenyl methyl ketone may be prepared by the Friedal-Craft s acylation of 3-fluorobiphenyl with aeetyl ehloride whieh upon Wilgerodt reaetion followed by esterification yields the corresponding aeetie ester. This on treatment with sodium ethoxide and ethyl carbonate yields a malonate which on alkylation forms a monoethyl eompound. The resulting product on subsequent hydrolysis and concomitant decarboxylation yields flurbiprofen. 

The 2-arylpropionic acid class (2-APA) of nonsteroidal anti-inflammatory drugs (NSAlDs) (Table 1) is characterized by each member having an asymmetric carbon a to the carboxylic acid moiety. The R-enantiomer of this chiral center of some 2-APAs may undergo an in vivo inversion to the S-enantiomer. This inversion process varies substantially between the different members of this class and also varies between species of animal studied. The members of this class that are currently in clinical use include ibuprofen, ketoprofen, tiaprofenic acid, fenoprofen, and flurbiprofen. The majority are marketed as racemates. Naproxen and its sodium salt are internationally marketed as the pure S(-l-)-enantiomer, while ibuprofen and ketoprofen are now marketed in several European countries as the stereochemically pure S(-l-)-enantiomer. 

Magnesium hydroxide appears to improve the rate of absorption of some acidic NSAIDs (which become more soluble as the pH rises) such as ibuprofen and flurbiprofen. Why this increased the gastric toxicity of ibuprofen in the one pharmacodynamic study is unclear. Sodium bicarbonate appears to have a similar effect on rate of absorption. Aluminium antacids do not produce soluble salts with these NSAIDs, and may therefore reduce the rate/extent of absorption. 

A study in 7 healthy subjects found that the increase in renal osmolal clearance of a standard water load in response to furosemide 40 mg orally or 20 mg intravenously fell from 105% to 19% and from 140% to 70%, respectively, after flurbiprofen 100 mg was given. A single-dose study in 10 healthy subjects found that flurbiprofen 100 mg reduced the urinary volume, urinary sodium and urinary potassium, in response to oral furosemide 80 mg by 10%, 9%, and 12%, respectively." ... 

The acids (5 pmol of each) are dissolved in 100 ml of acetone and 250 mg of pentafluorobenzyl bromide (NB this is a strong lachrymalor, so appropriate precautions should be taken), and 50 mg of potassium bicarbonate are added. The mixture is refluxed for 3 hours and then 500 ml of ether and 200 ml of ethyl acetate are added. The combined solution is briefly washed with 10 ml of ether-saturated water and dried over sodium sulphate before evaporation to dryness. The residue is taken up in 100 ml of hexane containing 1% each of acetone and ether [94]. This widely quoted procedure is readily scaled down a much smaller-scale version has been described for the drug flurbiprofen [95]. 

Fig. 3 Electropherograms of a sample containing a mixture of seven compounds. Bare fused-silica capillary 50 cm (effective length, 37 cm)x50 (jim I.D. electrolyte 20 mM [X-CHTA] Tf2N] 6, 30 mM sodium cholate (1) Atenolol, (2) propranolol, (3) warfarin, (4) indoprofen, (5) ketoprofen, (6) ibuprofen and (7) flurbiprofen. Applied voltage (a) 25 kV and with /fX-ibuprofen (b) 18 kV and with 5-ibuprofen. Adapted from [41]...

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