Fludrocortisone tablets

Amphotericin B. Amphotericin B (3), an important polyene antibiotic, is administered almost exclusively via the intravenous route and is therefore discussed in more detail under the systemic antimycotics. The vaginal tablets contain 50 mg amphotericin B, and 100 mg tetracycline base per tablet (see also Antibiotics, tetracyclines). The tablets for oral use contain 50 mg amphotericin B, 250 mg tetracycline base, and 125 mg sodium hexametaphosphate. A combination ointment contains 1 mg fludrocortisone acetate, 2.5 mg neomycin, 0.25 mg gramicidin, and 1 g plastibase in addition to 30 mg amphotericin B (see also Antibiotics, peptides). 

The MAOIs cause significant hypotension, which is often the dose-limiting side effect of these drugs. Expansion of intravascular volume through administration of salt tablets or fludrocortisone may be an effective treatment. 

Infants with salt-wasting CAH require mineralocorticoid replacement therapy, usually with fludrocortisone (9oc-fluorohydrocortisone). In addition, they require sodium chloride (1-2 g/day) since the sodium content of both breast milk and common infant formulas is only sufficient to meet the requirements of healthy infants (White and Speiser, 2000). Older children often acquire a taste for salty foods and do not require daily sodium chloride tablets. Plasma renin activity may be used to monitor mineralocorticoid and sodium replacement. 

Santos-Montes, A. Gasco-L6pez, A.I. Izquierdo-Hornillos, R. Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC. Chromatographia, 1994, 39, 539-542 [simultaneous dexamethasone methylprednisolone (IS) tablets column temp 30 LOD 6 ng/mL non-interfering corticosterone, cortisone, deflazacort, fludrocortisone, fludrocortisone acetate, hydrocortisone, hydroxyprogesterone, methylprednisolone, prednisolone, prednisone, triamcinolone interfering triamcinolone acetonide]... 

Tablets. Weigh an amount of powdered tablets equivalent to about 10 mg of the steroid (3 mg for Fludrocortisone Acetate Tablets) into a separator and extract completely with successive quantities of chloroform. Filter each extract through a cotton-wool plug and filter paper, both moistened with chloroform, into a 250-ml graduated flask and dilute to volume with chloroform. Transfer a 5-ml aliquot of this solution to a flask, just evaporate the chloroform and dissolve the residue in reagent I. Dilute with reagent I to give a solution containing the specified amount of steroid in 10 ml (see Table 34). Pipette 10 ml of the solution into an amber-coloured, 25-ml graduated flask and complete by the general method from Add 2 0 ml of reagent II. . ...

Applies to Tablets of Cortisone Acetate, B.P. Tablets of Dexamethasone Tablets of Dexamethasone Acetate Tablets of Fludrocortisone Acetate Tablets of Methylprednisolone Tablets of Prednisolone, B.P. Tablets of Prednisone, B.P. 

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