Flow-injection analysis-mass spectrometry FIA-MS

The results of these studies differ from those observed by Schroder and co-workers that observed the disappearance of PFOS and PFOA from waste-water under anaerobic conditions [49,50]. In these studies, either PFOS or PFOA were spiked into a bioreactor containing wastewater and aqueous PFOS concentrations were monitored by flow injection analysis-mass spectrometry (FIA-MS) and by LC-MS. Under aerobic conditions, no losses of PFOS or PFOA were observed in aqueous samples collected from the bioreactors. Under anaerobic conditions, PFOS concentrations decreased rapidly within 2 days to below the detection limit. PFOA also decreased but at a slower rate and was not detectable after 25 days. After 2 days, the PFOS concentrations in water decreased to less than the detection limit. However, no evidence of mineralization of either PFOS or PFOA was observed in that degrada-... 

Flow injection analysis mass spectrometry (FIA-MS) has been reported to be a fast method for the characterization of combinatorial libraries (55,56). The method verifies the presence of the molecular ions of the expected product and side products or impurities but does not provide information on the quality of the analyzed samples. Significant improvements related to the increased analytical throughput, obtained by reducing the time between each injection without increasing the intersample carry-over from each analysis, were recently reported (57, 58). When coupled with RP-HPLC, FIA-MS allows the separation and the determination of the molecular weight of the components of each sample. This is normally enough to unequivocally attribute the structure of the expected library component and of any side products from a library synthesis. 

---