Findings in CR Nonhuman Primates

The characteristics of CR monkeys are summarized in Table 2 [72] and Fig. 12A-C [73]. CR monkeys weigh less [74] and have less total and abdominal obesity than controls [75], In addition, CR reduces body temperature and induces a transient reduction in metabolic rate [76], Young male CR monkeys also exhibit delayed sexual and skeletal maturation [72, 74]. In addition, several lines of evidence suggest that CR improves the disease risk in rhesus monkeys [72], CR monkeys have reduced blood glucose and insulin levels and improved insulin sensitivity [75], CR also reduces blood pressure and lowers the serum triglyceride and cholesterol levels [77]. In 

Summary of Pathophysiological Effects of Caloric Restriction (CR) in Rhesus Monkeys (Adapted from Reference 72) 

Findings Effect of CR in monkeys Agreement with rodent findings 

Growth hormone/insulin-like growth factor 1 l Yes 

decrease, ( increase, —no change, not reported, DHEAS dehydroepiandrosterone sulfate. 

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