Filter lifetime

This study shows the significant benefits of an MLP pump in handling shear-sensitive CMP slurries in single-pass applications and under normal turnovers ( 100) expected in a typical fab operation. Since, the MLC pump generated far fewer >lpm particles in shear-sensitive slurries, the filter lifetime for MLC pump-based slurry delivery systems should be longer than the other AOD or bellows pump-based systems, especially when relatively open (> 1 pm nominal rating) filters are used in the global loop and point-of-use (POU) locations. 

Lin Z, Vasilopoulos G, Adrian K, Blum R, Friedman P. CMP filter plugging mechanisms and filter lifetime optimization. Proceedings of the 4th International CMP-MIC. 1999. 

A process based on a nickel catalyst, either supported or Raney type, is described ia Olin Mathieson patents (26,27). The reduction is carried out ia a continuous stirred tank reactor with a concentric filter element built iato the reactor so that the catalyst remains ia the reaction 2one. Methanol is used as a solvent. Reaction conditions are 2.4—3.5 MPa (350—500 psi), 120—140°C. Keeping the catalyst iaside the reactor iacreases catalyst lifetime by maintaining a hydrogen atmosphere on its surface at all times and minimises handling losses. Periodic cleaning of the filter element is required. 

The liquid was applied and dried on cellulose filter (diameter 25 mm). In the present work as an analytical signal we took the relative intensity of analytical lines. This approach reduces non-homogeneity and inequality of a probe. Influence of filter type and sample mass on features of the procedure was studied. The dependence of analytical lines intensity from probe mass was linear for most of above listed elements except Ca presented in most types of filter paper. The relative intensities (reduced to one of the analysis element) was constant or dependent from mass was weak in determined limits. This fact allows to exclude mass control in sample pretreatment. For Ca this dependence was non-linear, therefore, it is necessary to correct analytical signal. Analysis of thin layer is characterized by minimal influence of elements hence, the relative intensity explicitly determines the relative concentration. As reference sample we used solid synthetic samples with unlimited lifetime. 

The lifetime of a filter is dependent on the concentration of dust, type of dust, airflow, and, of course, the selected final pressure loss. Filter material and filter construction are often a compromise or combination of filter effects and installation space. Low speed or large filter surface promotes efficiency, low pressure loss, but above all a longer lifetime. 

SINTEF. Lifetime Tests of Air Filters in Real Applications. STF A95027. Sintef, March 199.S. 

Finally the catalyst lifetime was tested, as together with activity it influences the costs of catalyst. The catalyst after completing the hydrogenation was filtered. 

Energy transfer by the trivial mechanism is characterized by (a) change in the donor emission spectrum (inner filter effect), (b) invariance of the donor emission lifetime, and (c) lack of dependence upon viscosity of the medium. 

Recently, SETA BioMedicals has developed a new near-infrared squaraine-based label Seta-633, which can be used to study the interaction between low-molecular-weight analytes and proteins using fluorescence lifetime as the readout parameter [19]. This label exhibits lower quantum yields and shorter fluorescence lifetimes when free in solution, but these values substantially increase upon interaction with proteins, which is contrary to tracers like Cy5 or Alexa 647. It was demonstrated in a model assay that a biotinylated Seta-633 binds to anti-biotin with high specificity. Importantly, the lifetime of Seta-633-biotin increases about 2.76 fold upon binding to a specific antibody (anti-biotin, MW =160 kDa), while the titration with BSA or nonspecific antibody does not result in a noticeable change in lifetime (Fig. 13). The label is compatible with readily available light sources (635 nm or 640 nm lasers) and filter sets (as for Cy5 or Alexa 647) and its... 

In general, the longer the sweep time the better the sensitivity since the filter time constant parameter can be set longer with consequent improvement in signal-to-noise ratio. In practice, however, sweep times are usually set in accordance with the expected lifetime of the radical species, the stability of the instrument, and the patience of the operator. Decay of the radical or drift of the spectrometer during a scan is clearly undesirable. The sweep time is most commonly set in the range 4-10 min. 

Spectral FLIM involves measuring the apparent lifetimes in a preparation at many wavelengths with the assistance of a spectrograph or a series of filters (see also Chapter 4, Figs. 4.7 and 4.8 depicting hyperspectral FLIM in the time domain). The goal of the measurement is similar to that of the multifrequency approach ... 

Instrumentally, spectral FLIM generates a spectrally resolved set of lifetimes by either introducing filters to provide spectral resolution or a spectrograph between the sample and image intensifier. The first such system was created for looking at the long lifetimes of lanthanide dyes [37]. Later, a spectral FLIM system was described for measuring from a two-dimensional (2D) area of a microscope field... 

This approach works similar to the scattering solution. The filters are replaced with a beam splitter and a mirrored surface is placed in the position of the sample [36, 40], Similar to the scattering solutions, the lifetime of the reflection process is assumed to be 0 ns. The remaining aspects of the approach are the same as for the scatterer. 

When using fluorophores of known lifetime, it is important to validate the lifetime used. Fluorescence lifetimes can be sensitive to concentration, temperature, pH, and other environmental variables. Fluorophores from different suppliers can have variable purity. As a result, one should not assume that a value reported in the literature will be exactly transferable to other labs and conditions. Users of the method should be particularly careful to use low concentrations of fluorophore (<10 /iM) to avoid a variety of processes which can perturb lifetimes in solution. There are a limited number of well characterized fluorophores. If one is not available for a particular wavelength this will require a change of filters leaving the method with nothing to recommend it over reflection and scatter. 

The accuracy with which a system can measure lifetimes depends on a number of different factors including calibration of the instrument, the number of detected photons and also the efficiency of the analysis routines. In addition, sources of background and scattered light should be eliminated. Emission filters should be chosen with great care to make sure that no scattered laser light reaches the detector. Detection of scattered excitation light results in a spurious fast component in the decay and complicates the interpretation of the data. The choice of emission filters is much more critical in FLIM than in conventional fluorescence intensity imaging methods. 

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