Filgrastim symptoms

Bone marrow suppression ZDV Onset Few weeks to months Symptoms Fatigue, risk of T bacterial infections due to neutropenia anemia, neutropenia 1. Advanced HIV 2. High dose ZDV 3. Preexisting anemia or neutropenia 4. Concomitant use of bone marrow suppressants Avoid in patients with high risk for bone marrow suppression avoid other suppressing agents monitor CBC with differential at least every 3 months Switch to another NRTI D/C concomitant bone marrow suppressant, if possible for anemia Identify and treat other causes consider erythropoietin treatment or blood transfusion, if indicated for neutropenia Identify and treat other causes consider filgrastim treatment, if indicated... 

Be aware of signs and symptoms of allergic reactions that may occur with peg-filgrastim... 

Most cytokines (including TNF-o-, IFN-r, IL-2, G-CSF (filgrastim), and GM-CSF) have very short serum half-lives (minutes). The usual subcutaneous route of administration provides slower release into the circulation. Each cytokine has its own unique toxicity, but some toxicities are shared. Thus, IFN-n, IFN-B, IFN-r, IL-2, and TNF- all induce fever, flu-like symptoms, anorexia, fatigue, and malaise. 

Sufficient data on the potential long-term effects of G-CSF in healthy volunteers are still lacking. In one study, 101 healthy donors who had received filgrastim for a median of 6 days were questioned after a median of 43 (range 34-74) months to assess their current health 70 donors also had a complete blood count (17). No unusual disease was detected and the blood connts were within the reference range. In 20 donors followed for 6-12 months after peripheral blood progenitor cell collection, there were no particular symptoms or hematological abnormalities (15). 

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