Fibrotic

Hemmann S, Graf J, Roderfeld M et al (2007) Expression of MMPs and TIMPs in liver fibrosis—a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 46 955-975... 

An atherosclerotic lesion consisting of a fibrotic cap surrounding a lipid-rich core. The lesion is the site of inflammation, lipid accumulation, and cell death. Also know as an atheroma. 

For a variety of reasons, lipid—mainly as triacylglycerol—can accumulate in the hver (Figure 25—6). Extensive accumulation is regarded as a pathologic condition. When accumulation of lipid in the Ever becomes chronic, fibrotic changes occur in the cells that progress to cirrhosis and impaired liver function. 

PNEUMOCONIOSIS A group of lung diseases of a chronic fibrotic character due to the inhalation and retention in the lungs of a variety of industrial dusts. The main diseases are asbestosis, silicosis, coalworkers pneumoconiosis and mixed-dust pneumoconiosis less common pneumoconioses are associated with talc, clay or aluminium. 

Mineral dust-induced ROMs contributes to pulmonary fibrosis, malignancy, hypersensitivity and emphysema (Doelman etctl., 1990 Kamp etui., 1992). The involvement of ROMs in pulmonary fibrotic reactions is indicated by the participation of PMN oxidants in the autoactivation of latent coUagenase (Weiss et al., 1985). Prolyl hydroxylase, a key enzyme in collagen fibril formation, has been shown to be dependent on the reaction of superoxide with prolyl residues (Myllyla et al., 1979). 

Sick sinus syndrome leading to sinus bradycardia occurs as a result of fibrotic tissue in the SA node, which replaces normal SA node tissue.12... 

Fibrotic changes on chest radiograph consistent with prior TB... 

Isoniazid Daily for 6 monthsd Not indicated for HIV-infected persons, those with fibrotic lesions on chest radiographs, or children. B (I) C (I)... 

Retroperitoneal fibrosis An accumulation of fibrotic tissues in the retroperitoneum (the anatomic space behind the abdominal cavity). Structures that lie behind the peritoneum are thus termed retroperitoneal. These structures include kidneys, the bladder, portions of the duodenum, portions of the colon, and the inferior vena cava. 

Chronic inflammation is a leading component and contributing event to the pathogenesis of fibrotic disease, where a normal inflammatory response to injury becomes a chronic, pathologic wound-healing response. 

Fibrotic disease results from epithelial injury and abnormal wound repair in the absence of preceding inflammation. 

Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003 100(14) 8407-8411. 

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