Fibroblast growth factors internalization

One key NMR-based study has focused on the evaluation of the dynamic properties of heparin-like hexasaccharides.20 The analysis of Tj, T2 and NOE 13C-NMR data of biologically active synthetic compounds has shown that the sulphation pattern strongly influences the internal dynamics, and supports the importance of the GAGs flexibility on the selectivity of the interaction with fibroblast growth factors. 

Wiedlocha A, Falnes P0, Rapak A, Munoz R, Klingenberg O, Olsnes S (1996) Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization. Mol Cell Biol 16 270-280. 

S. Bonnal, C. Schaeffer, L. Creancier, S. Clamens, H. Moinc, A.C. Prats, and S. Vagner, A single internal ribosome entry site containing a G quartet ENA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons, J Biol Chem 278, 39330-39336 (2003). 

L. Creancier, D. Morello, P. Mercier, and A.C. Prats, Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation, J Cell Biol 150, 275-281 (2000). 

Ferguson I, Schweitzer J, Johnson EMJ. Basic fibroblast growth factor receptor-mediated internalization, metabolism, and anterograde axonal transport in retinal ganglion cells. J Neurosci 1990 10 2176-2189. 

Roghani, M. and Moscatelli, D. (1992) Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. J. Biol. Chem. 267 22156-22162. 

Rusnati, M., Urbinati, C. and Presta, M. (1993) Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells Role of the low affinity heparin-like bFGF receptors. 7. Cell. Physiol. 154 152-161. 

Walicke, P.A. and Baird, A. (1991) Internalization and processing of basic fibroblast growth factor by neurons and astrocytes. J. Neurosci. 11 2249-2258. 

Wiedlocha A, Sorensen V. Signaling, internalization, and intracellular activity of fibroblast growth factor. Curr Top Microbiol Immunol 2004 286 45-79. 

A. Wells, D.A. Lauffenburger, Internalized epidermal growth factor receptors participate in the activation of p21ras in fibroblasts,/. Biol. Chem. 1999, 274, 34350-34360. 

Reddy, C.C., A. Wells, and D.A. Lauffenburger, Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptor is altered via differential EGF depletion effect. Biotechnological Progress, 1994, 10, 377-384. 

---