Fetus control

The alimentary symptoms may be overshadowed by neuromuscular dysfunction, accompanied by signs of motor weakness that may progress to paralysis of the exterior muscles or the wrist (wrist drop), and less often, of the ankles (foot drop). Encephalopathy, the most serious result of lead poisoning, frequendy occurs in children as a result of pica, ie, ingestion of inorganic lead compounds in paint chips this rarely occurs in adults. Nephropathy has also been associated with chronic lead poisoning (147). The toxic effects of lead may be most pronounced on the developing fetus. Consequendy, women must be particulady cautious of lead exposure (148). The U.S. Center for Disease Control recommends a blood level of less than 10 p.m per 100 mL for children. 

Adequate well-control led studies in pregnant women have not demonstrated risk to the fetus. 

Spironolactone is an antiandrogen which blocks androgen-receptors, alters steroidogenesis by adrenals and gonads and inhibits 5-a reductase. In doses of 100-200 mg daily it reduces sebum production and improves inflammatory acne in women. During treatment, birth control measures are required due to the risk of male fetus feminization. 

OCDD. Signs of maternal toxicity were not observed in rats given 100 or 500 mg/kg/day OCDD. Examination of the fetuses did not reveal changes in fetal body measurements, incidence of fetal resorptions, or incidence of any fetal anomaly among litters or the fetal population. At 500 mg/kg/day, the incidence of subcutaneous edema was significantly increased among the fetal population (23/100 compared with 8/156 in controls) but not among litters (9/18 compared with 6/28 in controls). 

OCDD caused embryotoxicity but was not teratogenic at 500 mg/ kg/day. OCDD and 2,7-DCDD caused neither teratogenicity nor embryotoxicity at 100 mg/kg/day. Khera and Ruddick (7) reported that the administration of 2 mg 2,7-DCDD/kg/day was associated with microscopic myocardial and pericardial lesions in rat fetuses. However, examination of sections of myocardium and pericardium from fetuses of dams treated with 100 mg doses in this study revealed no morphological differences from controls. 

Category B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women, or animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus. 

Category D Studies, adequate well-controlled or observational, in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. 

Male patients with RA must receive counseling about the effects of certain medications on their fertility and potential harm to the fetus. It is difficult to establish causality between use of a medication by a male and the effect on fertility or fetal development therefore, a conservative approach must be taken. Patients of childbearing potential and their partners must be counseled to (1) use proper birth control while undergoing treatment for RA and (2) discontinue medications at least 3 months before conception.37... 

Mink 1.0 mg/kg diet daily for 4 months then every other day for 4 months alternating with control diet High mortality after 4 months when subjected to cold stress significant placental transfer to the fetus 9... 

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