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Ferritin gene transcription

Lescure am, Proudhon D, Presey H, Ragiand M, Theil EC and Briat JF (1991) Ferritin gene transcription is regulated by iron in soybean cdl cultures. Proc Natl Acad Sd USA 88 8222-8226. [Pg.822]

Plants Iron signals are transduced to relieve trans-acting factors and derepress ferritin gene transcription. Animals Iron signals are transduced to relieve IRP binding to IREs and derepress ferritin mRNA translation. [Pg.189]

Phytoferritin transcription is induced by iron excess and repressed by iron deficiency in leaves as well as in roots in several plant species in the case of maize, there are two ferritin genes which are differentially regulated by two independent-signalling pathways, one involving an oxidative step and one dependent on the plant growth hormone, abscissic acid. [Pg.139]

The existence of an iron-responsive cis-acting element in plant ferritin genes has been indicated in a series of studies. For example, iron-dependent induction of ferritin synthesis coincided with increased transcription and accumulation of ferritin mRNA [3]. Moreover, insertion of the animal IRE (mRNA iron responsive element) into soybean ferritin mRNA did not have much effect on the translation of the mRNA [4]. In addition, regulation of soybean ferritin expression in nodules [5] appeared to be posttranslational [6]. Finally, no IRE sequence was found in ferritin gene sequences from either maize or soybeans [7]. In fact, the organization of plant... [Pg.187]

For our model system, hepatic ferritin gene expression was monitored in response to interleukin-1 (IL-1) [71]. IL-1 was found to significantly increase ferritin translation by signaling though a novel translation enhancer element, the acute box motif, downstream from the IREs at the 5 cap site [45, 72]. This acute box motif is located immediately downstream from Iron-responsive Element in the 5 untranslated regions of both the L- and H-ferritin transcripts [73], and was also found to be present in front of the start codon in the APP transcript [47]. This observation was consistent with the pattern of both APP and ferritin expression in response to inflammation during both Alzheimer s disease and the anemia associated with chronic disease. [Pg.222]

Ascorbate can also serve as a signal. In cultured cells, which are usually deficient in vitamin C, addition of ascorbate causes an enhanced response to added iron, inducing synthesis of the iron storage protein ferritin.11 Ascorbate indirectly stimulates transcription of procollagen genes 1 and decreases secretion of insulin by the pancreas.)) However, since its concentration in blood is quite constant this effect is not likely to cause a problem for a person taking an excess of vitamin C. [Pg.1067]

Figure 12-1 Constancy of environmental signal (Fe) and gene product (ferritin protein) with variable genetic regulatory mechanisms (DNA transcription or mRNA translation) in animals and plants. Figure 12-1 Constancy of environmental signal (Fe) and gene product (ferritin protein) with variable genetic regulatory mechanisms (DNA transcription or mRNA translation) in animals and plants.
Lessons from the genetic control of translation of ferritin mRNAS and transferrin receptor mRNA stability can be applied to the control of APP expression by iron. This information will be relevant to Alzheimer s disease pathology after applying these models of post-transcriptional control to APP gene expression. [Pg.219]


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See also in sourсe #XX -- [ Pg.188 , Pg.189 ]




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