Felodipine Warfarin

Itraconazole Alfentanil, alprazolam, astemizole, atorvastatin, buspirone, cisapride, cyclosporine, delavirdine, diazepam, digoxin, felodipine, indinavir, loratadine, lovastatin, midazolam, nisoldipine, phenytoin, quinidine, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, tacrolimus, triazolam, verapamil, warfarin... 

Fig. 4.1 Correlation of permeability and total hydrogen-bonding capacity for a series of structural heterogeneous compounds corticosterone (Co), testosterone (Te), propranolol (Pr), alprenolol (Al), warfarin (Wa), metoprolol (Me), felodipine (Fe), hydrocortisone (Hy),...

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

Clinically important, potentially hazardous interactions with abacavir, atorvastatin, bepridil, bupropion, carbamazepine, clarithromycin, cyclosporine, dexamethasone, digoxin, felodipine, fluticasone propionate, fosamprenavir, itraconazole, ketoconazole, lovastatin, methadone, midazolam, nicardipine, nifedipine, phenobarbital, phenytoin, rifabutin, simvastatin, sirolimus, St John s wort, systemic lidocaine, tacrolimus, tenofovir, trazodone, vinblastine, vincristine, voriconazole, warfarin, zidovudine... 

To meet the speed and high efficiencies in separations demanded by the pharmaceutical industry, combined HPLC methods have been frequently used to simultaneously determine combination products [67]. A stability-indicating method for the simultaneous determination of aspirin and warfarin in warfarin sodium/aspirin combination tablets has been recently developed and validated [68]. In another example [69], the simultaneous determination of enalapril (2) and its two degradants, enapril-DKP (3) and enalapril-diacid (4), and felodipine (5) and its degradant, named HI52/37 (6) was achieved using combined method approach. 

In pharmacological studies neither amlodipine nor felodipine affected the anticoagulant effects of warfarin. Similarly, although diltiazem may cause a minor decrease in warfarin metabolism, this did not alter the anticoagulant effect in two studies. 

In healthy subjects given warfarin until at steady state, felodipine 10 mg daily for 14 days did not alter the dose of warfarin required to maintain a stable INR, or the pharmacokinetics of 5- or R-warfarin. Because felodipine does not interact with warfarin it has been used as a control drug in retrospective cohort studies assessing warfarin drug interactions. ... 

Orthostatic hypotension occurred when levosimendan was given with isosorbide mononitrate. The haemodynamic effects of levosimendan were not significantly altered by captopiil, carvedilol or other unnamed beta blockers, or felodipine. Levosimendan does not alter the effects of warfarin. Itraconazole does not alter the pharmacokinetics of levosimendan. Levosimendan appears not to interact adversely with alcohoL... 

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