FceRI structure

Draber P. Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after FceRI aggregation. Mol. Cell Biol. 2001 21 8318-8328. 57. 

Figure 3.1 The structure of IgE showing the substitution of Cc2 for the hinge region and the location of the FceRI and II receptor sites.

Hulett MD, Brinkworth RI, C. McKenzie IF, Hogarth PM. Fine structure analysis of interaction of FceRI with IgE. J Biol Chem 1999 274 13345—13352. McDonnell JM, BeavU AJ, Mackay GA, Jameson BA, Komgold R, Gould HJ, Sutton BJ. Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor. Nature Struct Biol 1996 3 419—425. 

Baird B, Zheng Y, Holowka D. Structural mapping of IgE-FceRI, an immunorecep-tor complex. Acc Chem Res 1993 26 428-434. 

Ra C, Jouvin MH, Kinet JP. Complete structure of the mouse mast cell receptor for IgE (FceRI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J Biol Chem 1989 264 15323-15327. 

Since an extensive review about FceRI has been recently published (9), we encourage its reading for detailed information and references about the molecular structure of the receptor and the mechanisms of FceRI-mediated signal transduction. 

Garman SC, Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS. Structure of the Fc fragment of human IgE bound to its high-affinity receptor FceRI alpha. Nature 2000 406 259-266. 

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