Fatty acids disease treatment

Inositols, ie, hexaliydrobenzenehexols, are sugars that have received increasing study and are useful in the treatment of a wide variety of human disorders, including vascular disease, cancer, cirrhosis of the Hver, frostbite, and muscular dystrophy (269). Myoinositol esters prepared by reaction with lower fatty acid anhydrides are useful as Hver medicines and nonionic surfactants the aluminum and ammonium salts of inositol hexasulfate are useful anticancer agents (270). Tetraarjloxybenzoquinones are intermediates in the preparation of dioxazine dyes (266,271). The synthesis of hexakis(aryloxy)benzenes has also beenpubUshed (272). 

Xue et al. [30] prepared a vaginal suppository formulation containing miconazole nitrate and determined its content by P-matrix ultraviolet spectrophotometry. The production of the suppository was finished with melting by the excipient of glyceryl esters fatty acid of artificial synthesis. Quantitative assay was conducted with a P-matrix ultraviolet spectrophotometer. The suppository was smooth and met the clinical requirement of vaginal disease treatment. The method of assay was accurate. 

Membrane polyunsaturation also has potential in the treatment of human disease and trials of this approach are somewhat further along than with NO. For example, highly polyunsaturated omega-3 fatty acids are being... 

Acetylcholine Precursors. Your nerve cells produce acetylcholine from certain dietary precursors (choline and lecithin). Many early studies tried dietary supplements of these precursors. A precedent for this approach was established using the dopamine precursor, L-DOPA, a well-established treatment for Parkinson s disease. Unfortunately, this approach is ineffective in dementia. It appears that the daily doses of these fatty acid precursors needed to have any discernible impact on acetylcholine levels far exceed what an individual can reasonably take in a day. This approach has therefore been abandoned. 

Some cells require specific nutrients to maintain their function. These nutrients are included in some feeds for the patient to help fight disease and aid recovery. These are sometimes called nutraceuticals , a term which can be loosely defined as a fuel or substrate that is provided by the physician or surgeon as part of the treatment for a specific condition. They include nucleotides, arginine, cysteine, glutamine and polyunsaturated fatty acids. The metabolic bases for the beneficial effects are described in Chapter 15. A summary is given below. 

As an example, bis(trifluoromethyl) carbinols have been described as strong inhibitors of malonyl-CoA decarboxylase, an enzyme involved in the metabolism of fatty acids, a possible target for the treatment of ischemic heart disease and diabetes (Figure 7.24)." Although few enzymological data are available, it is reasonable to... 

Fish oil has been one of the hottest topics in general nutrition and health care over the past few years, mainly because it is primarily composed of - fatty acids. The benefits of fish oil have a strong foundation in well-documented scientific studies, the most important ones dealing with the treatment of heart disease. Treatment of any condition associated with essential fatty acid changes inevitably involves the use of fish oil or more specific mixtures of the primary important essential fatty acids [14]. 

The branched-chain fatty acid, phytanic acid, is not a substrate for acyl CoA dehydrogenase due to the methyl group on its third (P) carbon (Figure 16.22). Instead, it is hydroxylated at the a-carbon by fatty acid a-hydroxylase. The product is decarboxylated and then activated to its CoA derivative, which is a substrate for the enzymes of P-oxidation. [Note Refsum disease is a rare, autosomal recessive disorder caused by a deficiency of a-hydroxylase. This results in the accumulation of phytanic acid in the plasma and tissues. The symptoms are primarily neurologic, and the treatment involves dietary restriction to halt disease progression.]... 

Treatment cf these disease states may be based on vaccination or drugs. In some cases, e.g. swine dysentery, no vaccines are available, so antibiotic treatment is essential. Antibiotic administration may be prophylactic or therapeutic with pigs, in particular, agents to control dysentery are routinely added to feedstuff or drinking water. The route of administration may also be highly important. For instance, in ruminants the preferred mode is injection, e.g. parenterally. The oral route, which introduces antibiotics directly into the rumen, may upset the delicate balance of rumen bacteria which are necessary to ferment carbohydrates to fatty acids — an essential component of the energy supply of ruminants. 

Staben P, Albring M. Treatment of patients with peripheral arterial occlusive disease Fontaine stage III and IV with intravenous iloprost an open study in 900 patients. Prostaglandins Leukot Essent Fatty Acids 1996 54(5) 327-33. 

Freund-Levi Y., Eriksdotter-Jonhagen M., Cederholm T., Basun H., Faxen-Irving G., Garlind A., Vedin I., Vessby B., Wahlund L. O., and Palmblad J. (2006). Fatty acid treatment in 174 patients with mild to moderate Alzheimer disease OmegAD study - A randomized double-blind trial. Arch. Neurol. 63 1402-1408. 

Carnitine is used as a dietary supplement by endurance athletes and in the treatment of certain metabolic diseases. Apparently the extra carnitine allows more rapid transport of fatty acids and a more efficient energy metabolism. 

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