Fast or High-Speed Gas Chromatography

One to three actual runs must be performed using the gas chromatographic separation that is to be modeled. The ability to use one to three runs is provided to give flexibility to the user. All data input runs must be carried out isobaric conditions (with constant column head pressure). There are no temperature restrictions, and the mns may be isothermal, or consist of up to two ramp profiles and three isothermal segments. 

If two data input runs are used, the only requirement is that they differ significantly in temperature conditions. In general, the calculation error for a particular compound decreases as the retention time difference between the two runs increases. For example, if data input run 1 was mn isothermally at 100°C, and data input run 2 was run isothermally at 105°C, the retention differences between the two mns would be rather small and may introduce more error that if data input mn 2 was mn isothermally at 150°C. The two runs can be any combination of isothermal and/or ramp segments as needed, and there is no requirement that either mn be made under the same temperature range or the same number of isothermal and ramp segment combinations. 

A third data input run can be entered, if desired, for more accurate pressure calculations. It needs to be performed under the same temperature conditions as one of the other two mns, except at a different column head pressure. The information GC-SOS requires from the data input runs is at the minimum-running conditions, retention times for each compound, and column holdup time. If desired, peak width and area inputs may be entered if not, GC-SOS supplies a default value for these. GC-SOS requires that column dimension data be supplied for all flow calculations. Additional descriptive information can also be entered for convenient record-keeping purposes and may also be found at www.chemsw.com. 

Areas of intense research interest include the entire spectrum of fast or high-speed gas chromatography (HSGC) (8), tunable column selectivity for HSGC and GC/MS 

Time of analysis in chromatography is defined by the retention time tm for the last target-component peak to elute from the column  

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The new-generation sensitive detection instruments are ideal for combining with high-speed GC or comprehensive two-dimensional gas chromatography (GC X GC), the two most promising recent developments in GC, for the identification and quantification of complex environmental samples, which require an extremely fast acquisition rate. ... 

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