Fangchinoline

Among other alkaloids closely related to tetrandrine is fangchinoline (item 15d list, p. 351), a demethyltetrandrine already described loc. cit.). [Pg.356]

Fangchinoline (40), a 4> 5-benzylisoquinoline alkaloid isolated from Stephania tetrandra S. Moore (family Menispermaceae), was evaluated to possess significant antihyperglycemic activity studied in streptozotocin (STZ)-induced diabetic ddY mice in a dose-dependent manner the drug reduced the blood glucose level of diabetic mice by 52.7 6.7% when administered in 14 h-fasted diabetic mice at a dose of 1 mg/kg. Blood... [Pg.534]

Tsutsumi T, Kobayashi S, Liu YY, Kontani H. (2003) Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra radix in strepto-zotocin-diabetic mice. Biol Pharm Bull 26 313-317. [Pg.586]

Stephania hemendifolia (Willd.) Walp. Qian Jin Teng (root) dl-tetrandrine, fangchinoline, 4-dementhyl-hasubanonine, isochondrodendrine, hemandine, stephisoferuline, hemandoline, hemandolinol, 3-O-demethylhemandifoline.33 Treat nephritic edema, urinary tract infection, rheumatic arthritis, sciatic neuralgia. [Pg.157]

The selective O-demethylation by HBr of tetrandrine (48) was studied under different conditions among the products were penduline (366), fangchinoline (367), atherospermoline (368), and, ultimately, the completely demethylated 369 (225). Cycleanine (112) was demethylated by HBr primarily to 370 and 371,... [Pg.106]

A TLC study of the alkaloids of Berberis vulgaris reported separation of oxyacanthine and berbamine (323). Berbamine was detected as a contaminant of berberine preparations (324). The chromatographic behavior of berbamine, oxyacanthine, and penduline was described (175). A quick method for serial determination of thalicarpine in Thalictrum species has appeared (325). Crude extracts and pure alkaloids of Thalictrum species have been examined in several TLC systems (326). The separation and semiquantitation of d-chondrocurarine chloride as a contaminant of d-tubocurarine chloride has been described (327) an improved TLC procedure for tubocurarine and commercial curare has appeared more recently (328). The behavior of tubocurarine on TLC plates of anion-exchange resin and fillers has been reported (329). Fangchinoline has been detected as a contaminant of tetrandrine by TLC (330). [Pg.129]

TLC separation and densitometric determinations of alkaloids of Cyclea densi-flora, Stephania herbacea, S. brachandra, and S. tetrandra have been described the bis bases isolated were isochondodendrine, curine, berbamine, cycleanine, cepharanthine, curarine, fangchinoline, homoaromoline, isotetrandrine (= iso-sinomenine A), and tetrandrine (= sinomenine A) (330a). A TLC-densitometric method for assay of dauricine from biological specimens has been reported (331). Tubocurarine served as a test case for pseudophase liquid chromatogra-... [Pg.129]

Fangchinoline Active against HeLa cells in vitro, not active toward Ehrlich ascites cells in mouse 360... [Pg.146]

Low-pressure column chromatography and pH gradient extraction were used to separate fangchinoline and tetrandrine from S. tetrandra root extracts (601). A quantitative method for determination of thalicarpine in pharmaceutical preparations using TLC-UV... [Pg.197]

Cycled barbata Miers (roots) Menispermaceae Berbamine (5) Chondocurine (8) a-Cyclanoline (9) /3-Cyclanoline (9) (//-Fangchinoline (6) Homoaromoline (5) Isochondocurine (5) Isotetrandrine (5) Limacine (5) ( )-Tetrandrine (5) Tetrandrine A/-2 -oxide (8) (+ (-Tetrandrine (4,5) Thalrugosine (isofangchinoline) (6)... [Pg.3]

Investigation of the Thai folk medicine, krung kha mao, the roots of Cyclea barbata Miers (formerly identified as Cissampelos pareira L.), has yielded many bisbenzylisoquinolines. other alkaloids d/-tetrandrine, isotetrandrine, limacine, berbamine, and homoaromoline (4,5). From the same plant, d/-fangchinoline, thalrugosine (d-isofangchinoline) (6), and the... [Pg.6]

Fangchinoline (bisbenzylisoquinoline) Isopyrum thalictroides, Pachygone dasycarpa, Stephania erecta (Menispermaceae) ACE [70]... [Pg.578]

Fangchinoline Isopyrum thalictroides, Pachygom dasycarpa ACE [Al, PAI, inhibits TXB2... [Pg.536]

A reversed phase HPLC-APCI-MS/MS method was developed to analyze filtered methanolic extracts of plant samples for the presence of the tetrahydroisoquinoline alkaloids tetrandrine and fangchinoline (Figure 13.4). In this way it was clearly shown that 9 of 10 samples purported to be S. tetrandra were in fact the toxic substituent Aristolochiafangchi whilst the tenth sample was unidentified but also unrelated to S. tetrandra [17]. [Pg.376]

Fig. 13.4 The tetrahydroisoquinoline alkaloids tetrandrine and fangchinoline extracted from Stephania tetrandra and analyzed using HPLC-APCI-MS/MS.

It follows from the structural relation of fangchinoline to tetrandrine that the former also has the SS-configuration (9). [Pg.153]

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