Antihyperglycemic activity

Fangchinoline (40), a 4> 5-benzylisoquinoline alkaloid isolated from Stephania tetrandra S. Moore (family Menispermaceae), was evaluated to possess significant antihyperglycemic activity studied in streptozotocin (STZ)-induced diabetic ddY mice in a dose-dependent manner the drug reduced the blood glucose level of diabetic mice by 52.7 6.7% when administered in 14 h-fasted diabetic mice at a dose of 1 mg/kg. Blood... 

Eysenhardtia platycarpa (family Leguminosae) were evaluated to possess promising antihyperglycemic activity by decreasing glucose level of streptozotocin (STZ)-induced diabetic rats (31 mg/kg of body weight, P< 0.05). 

Narvez-Mastache JM, Garduo-Ramrez ML, Alvarez L, Delgado G (2006) Antihyperglycemic activity and chemical constituents of Eysenhardtia platycarpa. JNat Prod 69 1687-1691. 

Manickam M, Ramanathan M, Farboodniay Jahromi MA, Chansouria JPN, Ray AB. (1997) Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 60 609-610. 

Antihyperglycemic activity. Dried seeds, administered orally to six patients with noninsulin-dependent diabetes mellitus at a dose of 50 g/person, was active. A single dose resulted in a glycemic index of 53 4HV047 extract of the dried fruit,... 

Scheen AJ, Lefebvre PJ. Troglitazone antihyperglycemic activity and potential role in the treatment of type 2 diabetes. Diabetes Care 1999 22(9) 1568-77. 

Yadav, S., Vats, V., Dhunnoo, Y. and. Grover, J.K. (2002) Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. Journal of Ethnopharmacology 82(2-3), 111-116. 

Scheme 4.16 The antihyperglycemic activity of the substance class depicted in the upper box depends crucially on the capacity to stabilize its preferred conformation by forming an intramolecular hydrogen bond between the amide hydrogen and a suitable acceptor / on the central aromatic moiety [22a]. The antiandrogenic activity ofthe compound in the lower box s based on stabilization of one conformer by two intramolecular hydrogen bonds [22b]. The trifluoromethyl group renders the o-hydroxy function a better hydrogen bridge donor and acceptor at the same time.

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