Expression of Molecular Information

Lehn JM. Programmed chemical systems multiple subprograms and multiple processing/ expression of molecular information. Chem Eur J 2000 6 2097-2102. 

Dynamical Expression of Molecular Information in Organic Crystals... 

Dynamical Expression of Molecular Information in Organic Crystals 519 26.4.2.3 Helical and Bundle Chirality in a 2, Assembly... 

Funeriu, D.P. Lehn. J.M. Fromm, K.M. Fenske, D. Multiple expression of molecular information Enforced generation of different supramolecular inorganic architectures by processing of the same ligand information through specific coordination algorithms. Chem. Eur. J. 2000. 6. 2103-2111. 

Lehn, J.-M. Programmed chemical systems Multiple subprograms and multiple processing/expression of molecular information. Chem. Eur. J. 2000. 6. 2097-2102. Swiegers, G.F. Malefetse. T.J. New self-assembled structural motifs in coordination chemistry. Chem. Rev. 2000. 100, 3483-3537. 

RNA has three basic roles in the cell. First, it serves as the intermediate in the flow of information from DNA to protein, the primary functional molecules of the cell. The DNA is copied, or transcribed, into messenger RNA (mRNA), and the mRNA is translated into protein. Second, RNA molecules serve as adaptors that translate the information in the nucleic acid sequence of mRNA into information designating the sequence of constituents that make up a protein. Finally, RNA molecules are important functional components of the molecular machinery, called ribosomes, that carries out the translation process. As will be discussed in Chapter 2, the unique position of RNA between the storage of genetic information in DNA and the functional expression of this information as protein as well as its potential to combine genetic and catalytic capabilities are indications that RNA played an important role in the evolution of life. 

The molecular mechanisms of the storage, transmission and expression of biological information. 

Information most probably entered nascent life with the appearance of RNA. One need only look at Figure 10.1 to realize that DNA can be dispensed with provided that RNA can be replicated. In such a DNA-free RNA world," RNA would have served both as the repository of genetic information and as the agent of the expression of this information, hrst by itself and later by way of its protein translation products. On the other hand, the key functions carried out by RNA molecules in protein synthesis indicate strongly that proteins - defined as special polypeptides made with a distinct set of twenty amino acids - are an invention of RNA. It has been proposed, because of the molecular complexity of RNA, that this substance may itself have been preceded by some simpler information-bearing molecule. This hypothesis, however, is unsupported by any evidence. 

Molecular Genetics is concerned with the expression of genetic information and the way in which this information contributes to the regulation of cellular functions. 

A variety of monomers can be trapped in the inclusion spaces at the molecular level and polymerized under suitable conditions. Such a reaction is called inclusion polymerization. " The study of inclusion polymerization started soon after the discovery of a honeycomb structure of urea inclusion compoxmds. The early study aimed to obtain highly stereoregular and asymmetric polymers in the spaces. Further studies brought about a profound understanding of the space effects from various viewpoints. Now. inclusion polymerization is classified between bulk or solution polymerization and solid state polymerization. In other words, it may be situated as low-dimensional and space-dependent polymerizations. Such a polymerization closely relates to supramolecular chemistry from a viewpoint of molecular information and expression. 

The study on inclusion polymerization by using steroidal hosts led us to the concept of molecular information and expression, as follows. It is theoretically considered that molecular information at a nanometer level may originate from sequential and chiral carbon chains, like proteins and steroidal molecules. As shown in Fig. 6a, the proteins express their molecular information through noncovalent bonds by the following processes molecular architecture (Fig. 6A). host-guest compounds (Fig. 6B), and reactions of the included guest components (Fig. 6C). Similarly, the steroidal molecules express their information through the noncovalent processes (Fig. 6b). Therefore, inclusion polymerization corresponds to one step of the expression process of molecular information that the sequential and chiral carbon-chains store. 

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