Excretion organic cations

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Octl [Slc22al]) gene, Mol. Cell. Biol. 2001, 23, 5471-5477. 

The existence of a carrier-mediated transport in nasal mucosa was first suggested by Kimura et al. [34], P-glycoprotein, organic cation transporter, dopamine transporter, and amino acid transporters have all been identified in the nasal mucosa, especially in the olfactory mucosa [31, 32, 35, 36], These transporters determine the polarized absorption and excretion of their substrates including amino acids, amines, and cations. 

M. Otsuka, T. Matsumoto, R. Morimoto, S. Arioka, H. Omote, and Y. Moriyama. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102 17923-17928 (2005). 

For example, some SLC on the sinusoidal (basolateral) membrane of hepatocytes take up organic anions, while the ABC on the apical membranes of bile canicular cells excrete them. The combined activities of these two transporters thus results in the vectorial transport of drugs from the blood to the bile. Similarly, the basolateral transporters of the kidney tubular cells act in a coordinated, vectorial manner with apical transporters to secrete organic cations (OCs) from the blood to the urine. 

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