Organic cations, biliary excretion

The (juaternary amines which are excreted in the bile in relatively small proportions of the dose differ from the compounds in Fig. 3 in that they lack a nonpolar ring structure at one end of the molecule. Schanker (1965) has suggested that this structural factor may be responsible for the differences in biliary excretion between the two kinds of organic cation. 

Also, there appear to bo two sejiaratc mechanisms in the liver for the secretion of organic anions and cations. Thus, Schanker and Solomon (1963) have studied the biliary excretion of the ijuaternary ammonium... 

SKF 525-A did, however, depress the rate of biliary excretion of indocyanine green. This dye has a complex chemical structure, with one eat ionic and two anionic centers (see structure XXXIII). The liver seems to have independent mechanisms for the secretion of organic cations and anions (Schanker and Solomon, 1963). Thus it i.s possible that indocyanine green is excreted by both pathways, while succinylsulfathiazole and phenolphthalein glucuronide can be secreted only by the anionic route. SKF 525-A does not affect the biliarv excretion of these two anions,... 

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