Operation control evidence

Mehrotra et al. (1997, 1999) presented preliminary evidence for the involvement of the thyroid and the hypophysis in DEHP-induced testicular toxicity in rats. They reported that hypothyroidism or hypophysectomy prevented, to some extent, DEHP-induced alterations in several xenobiotic-metabolizing enzymes in the testis. The significance of these findings is unclear due to a lack of DEHP-induced decreased testicular weight in sham-operated controls, which complicates comparison to the hypophysectomized animals. 

Control systans, in their broadest sense, include sensors, plant status indications, logic systans, alarm systems, and auto-control systems. With process plant digital systans, the control systems are usually referred to as the digital or distributed control systan (DCS). The DCS includes the human-machine interface (HMI) - the computa screens in the main control room - for the normal operation of the plant. The functions of the DCS are self-evidently to control the plant parameters within normal limits, and to advise the operators of plant status, and to raise alarms when normal parameter ranges are exceeded. 

By focussing on the synthetic benefits of MBFTs, one should recognize the opportunity for great diversification from easily accessible starting materials, which is an enormous benefit in medicinal chemistry. The concomitant economic benefits are evident through the savings on purification steps, use of solvents, batch reactors, and operational control. Finally, MBFT-based scaffold exploitation might considerably simplify lead compound optimization. 

Neural tissue response to wear debris was evaluated by applying 4 mg of particles onto the epidura of New Zealand white rabbits (n = 50, total). Five groups of rabbits were tested (n = 10, each) (1) sham operation (control) (2) stainless steel 316LVM (3) titanium alloy (Ti-6A1-4V) (4) CoCr alloy and (5) UHMWPE. The particle sizes ranged between 0.5 and 10 microns in diameter and were verified to be endotoxin free prior to implantation. Animals were sacrificed at 3 and 6 months postoperatively. Even though there was evidence of a chronic inflammatory reaction for all of the particles, it appeared localized within the... 

I am unaware of any evidence for rapidly operating control mechanisms which directly effect the activity of animal fatty acid synthetases. Instead, as we have seen, short-term control appears to be exerted primarily on Phase I enz3rmes,, acetyl-CoA carbo-... 

This would be induced or caused by operation, if the plant operators strangle valves to control production tlow. Any other discharge flow restriction (clogged filter, pipe obstruction, or tin-calibrated automatic valve) would produce the same evidence. Talk with the plant engineer about this situation and show him the evidence on the pump. 

The problem could be maintenance, operation, or design, or a combination of any or all these factors. In all honesty, you should never. see this set of evidence marks because it indicates a lack of control. Now because the mechanic cannot control operational problems or design problems, the first phase to correct this situation is to control the mechanical maintenance factors, like alignment, proper bolting and torque. sequences, be sure shafts are straight and round, and dynamically balance all rotary components. Reinstall the pump and wait for the next failure. Once the maintenance factors are under control, there should appear a clear vision and path to resolve any operational and/or design weaknesses. 

A situation where staff operate under self control is for telephone orders where there is little documentary evidence that a transaction has taken place. There may be an entry on a computer database showing that an order has been placed with a particular supplier. So how would you verify compliance with the requirements of this clause in such circumstances ... 

NOTE Although FT boilers usually do not operate under knife-edge control conditions (as do some large power WT boilers), it is evident that chelant programs generally are not suitable for any FT plant operating without benefit of a deaerator. 

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