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Etretin

The free acid analogue of the antipsoriatic agent etretinate (103) is prepared in substantially the same way as the parent compound. Thus, the aldehyde group in 98 is converted finally to the pho.sphonate (101) by sequential reduction (99), conversion to the chloride (100), and finally reaction with triethyl phosphite. Condensation of the ylide from 101 with the benzaldehyde 102 gives etretinate (103) saponification affords acitretin (104) [25]. [Pg.35]

Up to now, far more than 5000 retinoic acid analogs have been synthesized, out of which the following three generations have been established for therapy of various disorders First, the nonaromatic retinoids (3-carotene (provitamin A), alWraras-retinoic acid (RA) (tretinoin) and 13-cis-RA (isotretinoin), second, the monoaromatic retinoid derivatives trimethyl-methoxyphenyl analog of RA (etretinate) and9-(4-methoxy-2,3,6-trimethylphenyl)-... [Pg.1072]

Etretinate 0 i COOR Oral 0.25-1.0 mg/kg/d Generalized pustular psoriasis, exfoliative psoriasis, plaque psoriasis ... [Pg.1074]

Systemic treatment of 13-cis retinoic acid frequently leads to cheilitis and eye irritations (e.g., unspecific cornea inflammation). Also other symptoms such as headache, pruritus, alopecia, pains of joints and bone, and exostosis formation have been reported. Notably, an increase of very low density lipoproteins and triglycerides accompanied by a decrease of the high density lipoproteins has been reported in 10-20% of treated patients. Transiently, liver function markers can increase during oral retinoid therapy. Etretinate causes the side effects of 13-cis retinoid acid at lower doses. In addition to this, generalized edema and centrilobulary toxic liver cell necrosis have been observed. [Pg.1077]

C3H7NO 68-12-2) see Acrivastine Amlexanox Amrinone Etretinate Fluvastatin sodium Gitaloxin Glymidine Isradipine Lonazolac Nomegestrol acetate Sulfaperin... [Pg.2365]

C2H,BrMg 925-90-6) see Amfebutamone Dicthylstilbestrol Elhylestrenol Etretinate Fomocaine Indanorex Ketobemidone Mepivacaine Methadone Methallenestril Methohexital Normethadone Olprinone hydrochloride Retinol cthylmalonic acid diethyl ester see under diethyl ethylmalonate ethylmercaptan... [Pg.2382]

C gH, P 603-35-0) see Acrivastine Betacarotene Calcipotriol Canthaxanthin Cefixime cis-Cefprozil Etretinate llopfost Imiquimod Isotretinoin Repaglinide Retinol Tretinoin... [Pg.2452]

OiFFerential effects of and etretinate on serum cytokine levels in patients with psoriasis... [Pg.743]

Ethyl vinyl ether, 1 254, 258 derivation from ethanol, 10 557 physical properties of, l 255t Ethynylation, acetylene, 1 181, 231-249 Etretinate, 25 790 Etridiazole, 23 629... [Pg.337]

K. M. Knights, R. Gasser, W. Klemisch, In vitro Metabolism of Acitretin by Human Liver Microsomes Evidence for an Acitretinoyl-Coenzyme A Thioester Conjugate in the Transesterification to Etretinate , Biochem. Pharmacol. 2000, 60, 507-516. [Pg.536]

Ethinyl Estradiol 74 Ethmozne 50 Ethynodiol Diacetate 74 Etidonate 34 Etodolac 34 Etretinate ... [Pg.79]

See other pages where Etretin is mentioned: [Pg.314]    [Pg.254]    [Pg.237]    [Pg.613]    [Pg.613]    [Pg.614]    [Pg.1634]    [Pg.1748]    [Pg.820]    [Pg.2280]    [Pg.2284]    [Pg.2366]    [Pg.2380]    [Pg.2389]    [Pg.2410]    [Pg.2410]    [Pg.2410]    [Pg.2410]    [Pg.2410]    [Pg.2416]    [Pg.2451]    [Pg.2451]    [Pg.955]    [Pg.206]    [Pg.413]    [Pg.440]    [Pg.536]    [Pg.24]    [Pg.74]    [Pg.339]    [Pg.365]    [Pg.366]    [Pg.1303]    [Pg.1585]    [Pg.1599]   
See also in sourсe #XX -- [ Pg.509 ]



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