Etretinate Cyclosporine

Clinically important, potentially hazardous interactions with aluminum, aminophylline, carbamazepine, carbimazole, cyclosporine, daclizumab, diuretics, etoposide, etretinate, grapefruit juice, indomethacin, isoniazid, itraconazole, ketoconazole, licorice, live vaccines, methotrexate, naproxen, oral contraceptives, pancuronium, phenobarbital, phenytoin, rifampicin, troleandomycin... 

Acitretin, an oral retinoid, is the active metabolite of etretinate and has demonstrated clinical effects similar to etretinate, but with fewer adverse effects. Acitretin is indicated for the treatment of severe psoriasis, including erythrodermic and generalized pustular types, but is more useful as an adjunct in the treatment of plaque psoriasis. In contrast to the fast-acting cyclosporine and methotrexate, acitretin resolves psoriatic lesions more slowly. 

Korstanje MJ, Bessems PJMJ, van de Staak WJBM. Combination therapy cyclosporin-etretinate effective in erythrodermic psoriasis. Dermatologica (1989) 179,94. 

Brechtel B, Wellenreuther U, Toppe E, Czametzki BM Combination of etretinate with cyclosporine in the treatm ent of severe recalcitrant psoriasis. J Am Acad Dermatol (1994) 30, 1023-4. 

Webber IR, Back DJ. Effect of etretinate on cyclosporin metabolism in vitro. BrJ Dermatol... 

---