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Etoposide drug interactions

The calcium channel blocker mibefradil (Posicor ) was removed from the market in 1998. The headline for the Pink Sheets article describing this action was "Posicor Withdrawal Reflects Complexity of Interaction Profile" (59). Products identified as potentially dangerous in combination with mibefradil included cardiac drugs, such as amiodarone, flecainide, and propafenone oncologic products, such as tamoxifen, cyclophosphamide, etoposide, ifosfamide, and vinblastine and the immunosuppressant medications cyclosporine and tacrolimus. The sponsor s decision to withdraw mibefradil was based on the complexity of the drug interaction information that would have to be communicated to ensure safe usage. [Pg.515]

Schilder RJ, Hall L, Monks A, Handel LM, Fornace AJ Jr, Ozols RF, Fojo AT, Hamilton TC (1990) Metallothionein gene expression and resistance to cisplatin in human ovarian cancer. Int J Cancer 45 416-422 Sharma RP, Edwards IR (1983) Cisplatinum subcellular distribution and binding to cytosolic ligands. Biochem Pharmacol 32 2665-2669 Sherman SE, Lippard SJ (1987) Structural aspects of platinum anticancer drug interactions with DNA. Chem Rev 87 1153-1181 Shimizu T, Kubota M, Tanizawa A, Sano H, Kasai Y, Hashimoto H, Akiyama Y, Mikawa H (1990) Inhibition of both etoposide-induced DNA fragmentation and activation of poly (ADP-ribose) synthesis by zinc ion. Biochem Biophys Res Commun 169 1172-1177... [Pg.278]

Extensive structure modulations were performed to obtain more potent and less toxic anti-cancer agents, such as etoposide used in the therapy of numerous cancers (Fig. 41) [113], In contrast to podophyllotoxin, etoposide derivatives act as DNA topoisomerase II inhibitors. Tafluposide (F 11782) is an etoposide where both hydroxyl functions of the glycoside moiety are acylated with the pen-tafluorophenoxyacetic acid (Fig. 41). It has been demonstrated that tafiuposide does not act as a pro-drug of etoposide, but through a specific mechanism of interaction with both topoisomerases I and lla [114]. [Pg.589]

Inhibitors of topoisomerase I and topoisomerase II are the most commonly used anticancer drugs. The camp-tothecins—topotecan and rrinotecan (CPT-11)—interact with the enzyme topoisomerase I the podophyllotoxins— etoposide and teniposide—target topoisomerase II. They cause various forms of single- and double-strand breaks in DNA (1-7). Other drugs inhibit both enzymes simultaneously (8) (see below). [Pg.3454]

Burden, D. A., Kingma, P. S., Froelich-Ammon, S. J., Bjornsti, M.-A., Patchan, M. W., Thompson, R. B., and Osheroff, N. (1996) Topoisomerase II-etoposide interaction direct the formation of drug-induced enzyme-DNA cleavage complexes. J. Biol. Chem. 271, 29,238-29,244. [Pg.110]

Mechanisms Etoposide increases degradation of DNA, possibly via interaction with topoisomerase II, and also inhibits mitochondrial electron transport. TTie drug is most active in the late S and early G2 phases of the cell cycle. Teniposide is an analog with very similar pharmacologic characteristics. [Pg.482]

It was observed earlier that over expression of human N-terminal domain in yeast confers resistance to high concentrations of etoposide. The observed phenotype was proposed to be due to the competition of the excess of the N-terminal domain with the frill length enzyme for a limiting pool of inhibitor. So future challenge in the parasite topoisomerase II would be to develop drug resistant parasite strains and to see what causes this resistance and also to check what effect the individual domains of the enzyme have on the drug protein interaction in the context of the full-length enzyme. [Pg.109]

The UK manufacturer of aprepitant recommends caution when it is used with antineoplastics that are metabolised by CYP3A4, particularly irinotecan, because of the possibility of increased toxicity with this drug. They also mention that etoposide, vinoreibine, docetaxel, paclitaxel, ifosfamide, imatinib, vinblastine and vincristine, were given without dosage adjustment for potential interactions, but as this was not a formal interaction study they recommend caution. However, with intravenous docetaxel, it appears that no important changes in pharmacokinetics occur, and therefore dosage adjustments are unlikely to be needed for this drug,... [Pg.614]


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See also in sourсe #XX -- [ Pg.844 , Pg.1408 , Pg.1462 ]

See also in sourсe #XX -- [ Pg.386 ]

See also in sourсe #XX -- [ Pg.671 ]




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