Etomidate

Propanidid. Propanidid [1421-14-3] (Epontol), C gH2yNO, (7) a derivative of the propyl ester of homo vanillic acid, has been in clinical use in Europe for a number of years. Its main advantage is rapid onset of action and a fast recovery which, like etomidate, is because of rapid metaboHsm by esterases rather than redistribution (108). Excretion is rapid 75 to 90% of the dmg is eliminated as metaboUtes within two hours. Propanidid side effects include hypotension, tachycardia, and hyperventilation followed by apnea, as well as excitatory side effects such as tremor and involuntary muscle movement (109). 

Ethynodrel U 164 Ethynyl estradiol 1, 162 Etidocaine 95 Etinfidine 3, 135 Etoclofene 2, 89 Etomidate 3, 135... 

Ethyl chlorimidoacetate Oxyphencyclimine Ethyl chloroacetate Diltiazem HCI Etomidate HCI Piracetam Ticrynafen... 

The other method used is infusion of intravenous anaesthetics such as propofol, etomidate (for induction) and the barbiturates such as thiopental and pentobarbital. Investigations into the mechanism of anaesthesia have made use of all these compounds in order to identify a common mode of action linked to likely mechanisms within the CNS. 

Etomidate (Amidate), a nonbarbiturate, is used for induction of anesthesia Etomidate also may be used to supplement other anesthetics, such as nitrous oxide, for short surgical procedures. It is a hypnotic without analgesic activity. 

C,4H,ftN202S 84711-26-2) see Etomidate /V-ethoxycarbonyl-3-methoxy-8,14-didehydroinorphinan (C2(tH25N03i 58025-69-7) see Butorphanol 2 -e(hoxycarbonylmethoxy-4 -(3-methyl-2-butenyloxy)-acetophenone... 

R) -A -(ethoxycarbonylmethyl)-l-phenylethylamine (C12H17NO2 66512-37-6) see Etomidate lV -ethoxycarbonyl-2-methylpiperazine (QH16N2O2 120737-73-7) see Temafloxacin 7a-ethoxycarbonylmethylpyrrolizlne (CjjHjyN02 88069-56-7) see Pilsicainide 6-ethoxycarbonyl-2-methylthio-5-oxo-5,8-dihydro-pyrldo[2,3-d]pyrimidine... 

C4H7CIO2 105-39-5) see Azimilide hydrochloride Cloricromen Etomidate Ibuprofen Piracetam Retinol Tiaramide Tienilic acid ethyl 2-chloroacctoacetate... 

CgH N 3886-69-9) see Atorvastatin calcium Etomidate Neltinavir mesylate Repaglinide Tamsulosin hydrochloride (5)-a-methylbenzy lam ine... 

Hypnotics. Common hypnotics are thiopental, propofol, midazolam, etomidate, ketamine and inhaled anesthetics. The incidence of hypersensitivity reactions with thiopental is rare. Recently, thiopental was involved in less than 1% of allergic reactions in France [9]. Ever since Cremophor EL, used as a solvent for some non-barbiturate hypnotics, has been avoided, many previously reported hypersensitivity reactions have disappeared. In the last French surveys, reactions to propofol accounted for less than 2.5% of allergic reactions, and reactions to midazolam, etomidate or ketamine appear to be really rare [9]. Finally, no immune-mediated immediate hypersensitivity reaction involving isoflurane, desflurane or sevoflurane has been reported despite their wide use. 

Etomidate Inhibits 1 7, 20-lyase, 6 g/day Limited clinical hypokalemia, edema, hypertension. Injection-site pain, aminoglutethimide if used in combination. Intravenous route of administration... 

The GABA-gated chloride ion channel is modulated by several classes of drugs that bind to allosteric sites on the receptor complex the benzodiazepines, barbiturates and related intravenous general anesthetics such as etomidate and propofol, as well as anesthetic steroids and endogenous neurosteroids. It appears that some types of GABAa receptor are directly enhanced by ethanol and volatile general anesthetics (Fig. 16-2) [7,8,20]. 

Further, the removal of benzodiazepine sensitivity in a selective a subunit in a mouse using the gene knockin technique has established that the al subunit plays a major role in the sedative and amnesiac effects of benzodiazepines, part of the anticonvulsant effect and little of the anxiolytic effect the latter effects are more importantly mediated by the a2 subunit [5, 6], The 0 subunit selectivity for the drugs loreclezole (an anxiolytic) and etomidate (an anesthetic) allowed determination that a single residue in the M2 domain could account for this selectivity (02 = 03 >01). When a mouse knockin selectively removed the etomidate sensitivity of the 02 subunit, the animals showed reduced sensitivity to sedative effects of etomidate but no reduction of the true anesthetic effects. In contrast, mutation of the 03 subunit to negate etomidate sensitivity of that subunit alone resulted in a mouse with no sensitivity to the anesthesia produced by etomidate. This proved that the GABA receptor is the target of at least this one anesthetic (etomidate) and, furthermore, that the specific locations in the brain of 03 subunits are important for anesthetic action, while the... 

Etomidate is an imidazole derivative similar to ketoconazole that inhibits 11-hydroxylase. Because it is only available in a parenteral formulation, its use is limited to patients with acute hypercortisolemia awaiting surgery. 

ETOMIDATE INJECTION 20ML SYRINGE-NEEDLE UNIT 10 PER PACKAGE 6505012040631 PG 250 39 ... 

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