Etomidate nervous system

Etomidate hardly affects the autonomic nervous system. Since it inhibits cortisol synthesis, it can be used in the treatment of adrenocortical overactivity (Cushing s disease). 

The anesthetic effect of (+)-etomidate subsides within a few minutes owing to redistribution of the drug. Etomidate can provoke myoclonic movements that can be prevented by premedication with a benzodiazepine or an opioid. Because it has little effect on the autonomic nervous system, it is suitable for induction in combination anesthesia. Etomidate inhibits cortisol synthesis in subanesthetic doses and can therefore be used in the long-term treatment of adrenocortical overactivity (Cushing disease). 

Nervous System The effects of etomidate on cerebral blood flow, metabolism, and intracranial pressure (ICP) and intraocular pressure are similar to those of thiopental. Etomidate is not a proven treatment for seizures. 

Nervous system Etomidate 0.1 mg/kg has been used to activate the epileptogenic zone in 22 patients with temporal lobe epilepsy [23. Two patients were excluded from the... 

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