Etidocaine hydrochloride

Etidocaine hydrochloride (Duranest), although chemically similar to lidocaine, has a more prolonged... 

Dose. Etidocaine hydrochloride is administered by injection as 0.5 to 1.5% solutions maximum dose, 300 mg. 

Cyclobenzaprine Hydrochloride Pyrrobutamine Trimeperidine Hydrochloride Propamidine Dydrogesterone Ethisterone Ethopropazine Apomorphine Hydrochloride Molindone Hydrochloride Etidocaine Hydrochloride Benorylate Flunitrazepam Ethylmorphine Acecainide Hydrochloride Amoxapine... 

Emepronium Bromide Norethisterone Etidocaine Hydrochloride Pyridoxine Hydrochloride Dihydroergotamine Tartrate Hyoscyamine Sulphate Benzilonium Bromide Rimiterol... 

C)jHi)N 87-62-7) see Bupivacaine Etidocaine LicIocaine Lidoflazine Mepivacaine Pilsicainide Pyrrocaine Ropivacaine hydrochloride Tocainide Xipamide... 

Following are structural formulas for three local anesthetics Lidocaine was introduced in 1948 and is now the most widely used local anesthetic for infiltration and regional anesthesia. Its hydrochloride is marketed under the name Xylocaine . Etidocaine (its hydrochloride is marketed as Duranest ) is comparable to lidocaine in onset, but its analgesic action lasts two to three times longer. Mepivacaine (its hydrochloride is marketed as Carbocaine ) is faster and somewhat longer in duration than lidocaine. 

After determining cocaine s structure, chemists could ask, "How is the structure of cocaine related to its anesthetic effects Can the anesthetic effects be separated from the habituation effect " If these questions could be answered, it might be possible to prepare synthetic drugs with the structural features essential for the anesthetic activity but without those giving rise to the undesirable effects. Chem -ists focused on three structural features of cocaine its benzoic ester, its basic nitrogen atom, and something of its carbon skeleton. This search resulted in 1905 in the synthesis of procaine, which almost immediately replaced cocaine in dentistry and surgery. Lidocaine was introduced in 1948 and today is one of the most widely used local anesthetics. More recently, other members of the "caine" family of local anesthetics have been introduced (e.g., etidocaine). All of these local anesthetics are administered as their water-soluble hydrochloride salts. 

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