Ropivacaine hydrochlorid

C)jHi)N 87-62-7) see Bupivacaine Etidocaine LicIocaine Lidoflazine Mepivacaine Pilsicainide Pyrrocaine Ropivacaine hydrochloride Tocainide Xipamide... 

CjHiiNOj 3105-95-1) see Ropivacaine hydrochloride pipecolinic acid 2,6-xylidide... 

C2H7Br 106-94-5) see Prajmalium bitartrate Promestriene Ropivacaine hydrochloride Valproic acid propylene... 

Ropivacaine hydrochloride is a long-acting local anesthetic, which is manufactured as the pure S-enantiomer. The enantiomeric purity is determined by CZE, using heptakis-(2,6-di-0-methyl)-j5-cyclodextrin as chiral selector. A resolution of 3.7 between the two enantiomers is required for the system suitability solution. The percentage R-enantiomer is calculated relative to the S-enantiomer in the same electropherogram, and should not exceed 0.5%. In Eigure 5, a representative electropherogram is presented. 

Ropivacaine hydrochloride USP and Ph.Eur. Enantiomeric purity Small organic compound na ... 

Sanger-van de Griend, C. E., Wahlstrom, H., Groningsson, K., and Widahl-Nasman, M. (1997). A chiral capillary electrophoresis method for ropivacaine hydrochloride in pharmaceutical formulations validation and comparison with chiral liquid chromatography. /. Pharm. Biomed. Anal. 15(8), 1051-1061. 

European Directorate for the Quality of Medicines. (2006). Ropivacaine hydrochloride monohydrate. Pharmeuropa 18(1), 141—143. 

K2C03 (0.32 kg), Nal (catalytical amount), and 1-bromopropane (0.28 kg) and about 5% of water, were added to the organic phase from the previous step. The mixture was heated to reflux to complete the reaction. The excess of bromopropane was removed by distillation. The reaction mixture was extracted with water (1.70 L). Acetone (1.70 L) was added to the organic phase followed by HCI (aq) to pH about 2. The solution was seeded. The crystal slurry was cooled to 9°C. The crystals were collected by centrifugation and were washed with acetone. The product was used directly in the next step and was not dried. Yield (calculated on the dry basis) 0.47 kg of ropivacaine hydrochloride (about 0.90%). 

C. The crystals were collected by centrifugation and were washed with acetone. The product was used directly in the next step and was not dried. Yield (calc, on the dry basis) 0.47 kg of ropivacaine hydrochloride (about 0.90%). 

Plowman AN, Bolsin S, Mather LE. Central nervous system toxicity attributable to epidural ropivacaine hydrochloride. Anaesth Intensive Care 1998 26(2) 204-6. 

Ropivacaine hydrochloride is quite soluble in water and ethanol. 

Ropivacaine hydrochloride injection 0.2% w/v and infusion 0.2% w/v for epidural pain relief. 

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