Etidocaine

Etidocaine is a long-acting derivative of lidocaine but is far more potent. It is effective for infiltration anesthesia, peripheral nerve block, and epidural and caudal blockade. 

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R = / -C H ), in low doses, exhibits the former behavior and is used primarily as an extradural agent in obstetrics. The lowest effective extradural concentration of etidocaine (21, X = CH, R = R = 2H, R = / -C H ), however, shows both adequate sensory and profound motor blockade so that it is useful in surgical situations where maximum neuromuscular blockade is necessary. In an isolated nerve preparation, bupivacaine blocks unmyelinated C fibers which are mainly responsible for pain perception at a much greater extent than the myelinated A fibers which carry motor impulses. It is postulated that absorption of bupivacaine by the vasculature at the site of injection, combined with the slow diffusion of this agent, results in an insufficient amount of the drug penetrating the large A fibers to cause motor conduction blockade. Clinically, motor block can be observed in some procedures. 

Etidocaine (21, X = CH, R = R = R = characterized by high efficacy, short onset, and long duration of action, may be used for... 

Ethynodrel U 164 Ethynyl estradiol 1, 162 Etidocaine 95 Etinfidine 3, 135 Etoclofene 2, 89 Etomidate 3, 135... 

Diethyl sodium phthalidomalonate Melphalan Diethyl sulfate Aminometradine Etidocaine HCI Fluorouracil Pipemidic acid Piprozolin Piromidic acid... 

C)jHi)N 87-62-7) see Bupivacaine Etidocaine LicIocaine Lidoflazine Mepivacaine Pilsicainide Pyrrocaine Ropivacaine hydrochloride Tocainide Xipamide... 

C 5H2gN03 188923-19-5) see Nelfinavir mesylate (l,l-dimethyl-2-phenylethyl)methylamine (C HnN /00-92-5) see Oxetacaine l-[(3,4-dimethylphenyl)iminol-l-deoxy-D-rihitol (C11H19NO4) see Riboflavin N-(2,6-dimethylphenyl)-2-iodobutanamide (C,2H 16INO 60119-84-8) see Etidocaine... 

C Hi N I07-W-H) see Carticaine Cropropamide Etidocaine Prilocaine Propafenone propyl benzenesulfonate (CjHijOjS KO-42-2) see Propoxycaine propyl bromide... 

The clinical success of hindered acetanilide derivatives, such as lidocaine, of course, resulted in the synthesis of many analogues. Branching in the acid moiety is consistent with activity as demonstrated by the local anesthetic properties of etidocaine (48)... 

Etafedrine, 39 Etazolate, 469 Eterobarb, 304 Ethacrynic acid, 103 Ethamivan, 94 Ethonam, 249 Ethynerone, 146 Etidocaine, 95 Etoclofene, 89 Etorphine, 321 Etoxadrol, 285... 

Etidocaine hydrochloride (Duranest), although chemically similar to lidocaine, has a more prolonged... 

C. Lidocaine is well tolerated and has a rapid onset and an adequate duration of action for most procedures. Bupivacaine has a particularly long duration of action. This may be advantageous in certain procedures, but not in most. Procaine has a relatively slow onset of action as well as a short duration of action. Etidocaine shows a preference for motor rather than sensory block this limits its effectiveness in obstetrics. 

Rx with etidocaine (Duranest with Epinephrine) with prilocaine (Citanest Forte) ... 

The local anesthetics can be broadly categorized on the basis of the chemical nature of the linkage contained within the intermediate alkyl chain group. The amide local anesthetics include lidocaine (7.5), mepivacaine (7.6), bupivacaine (7.7), etidocaine (7.8), prilocaine (7.9), and ropivacaine (7.10) the ester local anesthetics include cocaine (7.11), procaine (7.12), benzocaine (7.13), and tetracaine (7.14). Since the pharmacodynamic interaction of both amide and ester local anesthetics with the same Na" channel receptor is essentially idenhcal, the amide and ester functional groups are bioisosterically equivalent. However, amide and ester local anesthetics are not equal from a pharmacokinetic perspective. Since ester links are more susceptible to hydrolysis than amide links. 

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