Apomorphine hydrochloride

To identify the presence of undesirable specific organic compounds present as impurities in a number of pharmaceutical substances, namely morphine in apomorphine hydrochloride hydrazine in carbidopa 3-aminopropanol in dexampanthenol etc.,... 

Procedure Prepare the chromatogrphic tank by lining the walls with sheets of filter paper pour the mobile-phase into the tank, saturating the filter paper in the process, to a depth of 5 to 10 mm, close the tank and allow it to stand at 20° to 25 °C for 1 hour for equilibration of the mobile-phase in the chromatank. Apply separately to the TLC plate 5 (il of each of two solutions (1) and (2) of apomorphine hydrochloride and (3) of morphine in the form of circular spots about 2 to 6 mm in diameter, and 15 to 20 mm from one end of the plate and not nearer than 10 mm to the sides the two spots must be at least 10 mm apart. Mark the sides of the plate 15 cm from the line of application. Allow the solvent to evaporate and place in the chromatank,... 

Apomorphine hydrochloride (44 Apokyn ) Morphine (43) Alkaloid Semi-synthetic NP Plant Parkinson s disease Potent dopamine receptor agonist 403 16... 

Apomorphine hydrochloride (44 Apokyn Bertek, 2004), is a semisynthetic derivative of opium alkaloid morphine (43) isolated from poppy (Papaver somniferum), and it has long been known for its erectile activity at the effective dose of 2-6 mg physicians discovered the effect over 100 years ago, but found the drug, at a much higher dose (ca. 200 mg), to be more suitable for poison victims as an emetic because it also causes serious nausea and vomiting. Apomorphine exerts its erectile effect at the central nervous system the drug has been found to be a non-selective dopamine agonist which activates both Di-like and D2-like... 

Subcutaneous injection of apomorphine hydrochloride (Apokyn), a potent dopamine agonist, is effective for the temporary relief ("rescue") of off-periods of akinesia in patients on optimized dopaminergic therapy. It is rapidly taken up in the blood and then the brain, leading to clinical benefit that begins within about 10 minutes of injection and persists for up to 2 hours. The optimal dose is identified by administering increasing test doses until adequate benefit is achieved or a maximum of 10 mg is reached. Most patients require a dose of 3-6 mg, and this should be given no more than about three times daily. 

Apomorphine hydrochloride (Figure 44.2), an alkaloid obtained in the laboratory by rearrangements within the morphine molecule, is a grayish-white, glistening, light-sensitive, and air-sensitive crystalline powder, soluble in both water and alcohol in the proportions of about 1 50 it is available in small amounts in bulk and more easily as 5 mg (1/12 grain) tablets. 

Dose. 100 tig/kg of apomorphine hydrochloride subcutaneously, as a single dose. 

Cyclobenzaprine Hydrochloride Pyrrobutamine Trimeperidine Hydrochloride Propamidine Dydrogesterone Ethisterone Ethopropazine Apomorphine Hydrochloride Molindone Hydrochloride Etidocaine Hydrochloride Benorylate Flunitrazepam Ethylmorphine Acecainide Hydrochloride Amoxapine... 

Apomorphine hydrochloride, 357 Aponal, 573 A-Poxide, 446 Apozepam, 526 Appetitziigler, 617 Apresolin(e), 662 Apressinum, 662 Apricot kernels, 352 Aprindine, 358 Aprindine hydrochloride, 358 Aprinox, 375 Aprobarbital, 358 Aprobarbitone, 358 Aprobarbitone diol, 359... 

Apomorphine Hydrochloride, USP. When morphine or morphine hydrochloride is heated at 140° under pressure u ilh strong (.35%) hydrochlorie aeid. it loses a molecule of water and yields a eompound known as apomorphine. 

---