Ethyl isobutyrate

In this section primarily reductions of aldehydes, ketones, and esters with sodium, lithium, and potassium in the presence of TCS 14 are discussed closely related reductions with metals such as Zn, Mg, Mn, Sm, Ti, etc., in the presence of TCS 14 are described in Section 13.2. Treatment of ethyl isobutyrate with sodium in the presence of TCS 14 in toluene affords the O-silylated Riihlmann-acyloin-condensation product 1915, which can be readily desilylated to the free acyloin 1916 [119]. Further reactions of methyl or ethyl 1,2- or 1,4-dicarboxylates are discussed elsewhere [120-122]. The same reaction with trimethylsilyl isobutyrate affords the C,0-silylated alcohol 1917, in 72% yield, which is desilylated to 1918 [123] (Scheme 12.34). Likewise, reduction of the diesters 1919 affords the cyclized O-silylated acyloin products 1920 in high yields, which give on saponification the acyloins 1921 [119]. Whereas electroreduction on a Mg-electrode in the presence of MesSiCl 14 converts esters such as ethyl cyclohexane-carboxylate via 1922 and subsequent saponification into acyloins such as 1923 [124], electroreduction of esters such as ethyl cyclohexylcarboxylate using a Mg-electrode without Me3SiCl 14 yields 1,2-ketones such as 1924 [125] (Scheme 12.34). 

Base catalyzed condensation reactions of esters and ketones have an additional factor of importance in determining the product, and this is the fact that the overall reaction, as well as the intermediate steps, is highly reversible. The final product may be rate or equilibrium determined, and in the latter case the result may depend on the relative acidity of the various possible products. In a highly basic medium the product will be partly in the form of a salt and the stability of the salt is then a product-determining factor. Failure of a condensation to take place may be due either to an insufficiently high concentration of carbanions or to the instability of the product. The reactions of ethyl isobutyrate will illustrate both points.419... 

Ethyl isobutyrate, azeotropic mixtures with butyl alcohols, 4 395t Ethyl lactate preparation, 10 489 Ethyl linalool, 24 503 Ethyl linoleate, cosmetically useful lipid, 7 833t... 

METHYL ISOBUTYL KETONE n-PENTYL FORMATE n-BUTYL ACETATE sec-BUTYL ACETATE tert-BUTYL ACETATE ETHYL n-BUTYRATE ETHYL ISOBUTYRATE ISOBUTYL ACETATE n-PROPYL PROPIONATE CYCLOHEXYL PEROXIDE DIACETONE ALCOHOL 2-ETHYL BUTYRIC ACID n-HEXANOIC ACID 2-ETHOXYETHYL ACETATE HYDROXYCAPROIC ACID PARALDEHYDE... 

ETHYL ISOBUTYRATE 6.6661 -2.3847E+03 2.1818E+00 -1.0957E-02 6.8003E-06 185 553... 

I. The Condensation of Ethyl Isobutyrate to Ethyl Isobutyryl-isobutyrate. 

Using the same approach, we can combine all other important volatile ingredients of a strawberry to form specific bases. All fruity esters like ethyl butyrate, ethyl caproate or ethyl isobutyrate can be combined to a fruity base , and all caramel-like ingredients to a caramel base , and so on. Finally, all major flavour characters of a strawberry can be obtained by appropriate combination of only a few bases. 

Ethyl isobutyrate [623-48-3] M 116.2, b 110", d 0.867, n 1.388. Na2CO3, then with saturated aqueous CaCl2. Dried with CaSOa and distd. 

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