Ethyl- -hydroxy propionate

The Reformatsky Reaction consists of the interaction of an ester of an a-halogeno-acid with an aldehyde, a ketone or another ester in the presence of zinc. For example, if a mixture of ethyl bromoacetate and benzaldehyde is heated with zinc, the latter undoubtedly first combines with the ethyl bromoacetate to form a Grignard-like reagent (reaction A), which then adds on to the benzaldehyde Just as a Grignard reagent would do (reaction B). The complex so formed, on acidification gives ethyl p-phenyl-p-hydroxy-propionate (reaction C). Note that reaction A could not satisfactorily be carried out using... 

Chemical Designations - Synonyms Ethyl Alpha-hydroxy-propionate Ethyl 2-hydroxypropanoate Ethyl DL-Lactate Lactic Acid Ethyl Ester Chemical Formula CH3CHOHCOOC2H3 Observable Characteristics - Physical State (as shipped) Liquid Color Colorless Odor Mild characteristic. 

Hydroxy-propionic acid 1,3-Propanediol, acrylamide, acrylic acid, acrylonitrile, ethyl-3-hydroxypropionic acid, L-alanine, L-serine, malonic acid, propiolactone, poly(3-HP), poly(3-hydroxybutyric acid-co-3-hydroxypropionic acid) Polymers, fine chemicals Cao et al., 1999 Werpy and Petersen, 2004 Zhang etal., 2004 Patel etal., 2006... 

Ethyl Lactate Ethyl Alpha-Hydroxy-Propionate Ethyl 2-Hydroxy- Propanoate Ethyl Dl-Lactate Lactic Acid Ethyl Ester... 

Ethyl-S(-)-2-hydroxy propionate Ethyl-(S)-2-hydroxy propionate. See Ethyl-(S)-lactate 2-Ethyl-3-hydroxy-4H-pyran-4-one. See Ethyl maltol... 

Further improvements resulted from the use of a probe for sonication.325 Jhe higher reactivity seems not to be due to an increased surface area, but rather to morphological and composition changes, as evidenced by electron microscopy and sputtered neutral mass spectrometry.i< When applied to ethyl bromo propionate and trifluoroacetaldehyde, the resulting p-hydroxy esters are obtained in good yields with predominance of the threo isomer.272... 

C5H10O3 2-hydroxy-propionic acid ethyl ester 97-64-3... 

C7H12O5 2-hydroxy-propionic acid 1-methoxycarbonyl-ethyl ester 2037-15-2... 

CsHijClOs 2-hydroxy-propionic acid l-(2-chloro-ethoxycarbonyl)-ethyl ester ... 

CioHigOg 2-hydroxy-propionic acid 1-butoxycarbonyl-ethyl ester 13544-80-4... 

C14H26O5 2-hydroxy-propionic acid 1-octyloxycarbonyl-ethyl ester 5394-45-6... 

Other classes of molecules which have been benzylated using this reagent include hydroxy ketones, hydroxy halides and esters such as tartrates, hydroxy propionates or butanoaies, long alkyl chain hydroxy esters, and hydroxy lactones. Under basic conditions problems such as enolization, aldol reactions, elimination and epoxide formation can cause problems and when 2-substituted esters, such as ethyl (5)-lactate, are required as homochiral starting materials, then protection using this method circumvents the considerable risk of racemization that accompanies the use of bases (eq 6). 

Ethyl-2-(3-hydroxy-4-amlnophenyl)propionate p-Chlorobenzoyl Chloride... 

A mixture of 50 grams of a-dl-1,2-diphenyl-2-hydroxy-3-methyl-4-dimethylaminobutane hydrochloride, 50 grams of propionic anhydride and 50 cc of pyridine was refluxed for about 5 hours. The reaction mixture was cooled to 50°C and ethyl ether was added to the point of incipient precipitation. The hydrochloride salt of 0 -dl-l,2-diphenyl-2-propion-oxy-3-methyl-4-dimethylamlnobutane formed in the reaction precipitated upon cooling and was removed by filtration and washed with anhydrous ether. On recrystallization from a mixture of methanol and ethyl acetate, a-dl-l, 2-diphenyl-2-propionoxy-3-methyl-4-dimethyl amlnobutane hydrochloride melted at 170°-171°C. 

Cyclopentyl- 3-(N-piperidyl)ethyl ketone Cycrimlne HCI /3-Cyclopentyl propionic acid Testosterone 17/3-cypionate Cyclopentyl (tt-thienyl) hydroxy acetic acid Penthienate bromide Cyclopropanecarboxylic acid chloride Prazepam... 

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