Ethyl ether, III

Ethyl bromide, I, i, 6-7 Ethyl 8-bromopropionate, HI, 51-52 Ethyl cyanoacetate. III, 53-56 Ethylene chlorohydrin, 111, 7 Ethyl ether. III, 47, 48 Ethyl hydracrylate. III, 52 Ethyl oxalate, II, 23-26 Ethyl phenylacetate, II, 27-28 Extraction, III, 88... 

H. W. Haggard, The absorption, distribution, and elimination of ethyl ether III. The relation of the concentration of ether or any similar volatile substance in the central nervous system to the concentrations in arterial blood, and the buffer action of the body. J Biol Chem 59 771-781 (1924). 

In this paper we report upon a detailed examination of the hexane extract (Fraction A) of 21 kg of the roots of II. littoralis. The dry hexane extract was subjected to chromatography on a silica gel column and eluted with a hexane/ethyl ether gradient. From the different fractions eluted, three crystalline compounds were isolated two of which are new natural products. The compounds described herein are tentatively named compounds II and III. The additional compound will be discussed in a future paper. 

A -3,4-cis-THC has now been found in Cannabis sativa (Phenotype III) other papers reporting the characterization of compounds from Cannabis sativa concern conclusive identification and synthesis of cannabinodiol, " which is known to result from the photochemical irradiation of cannabinol (Vol. 7, p. 51), and the identification of A -tetrahydrocannabinolic acid " and (+)-cannabitriol (263) " (263) and the corresponding C-2 ethyl ether may be epoxide-derived. " ... 

Triethylamine over cobalt(III) fluoride gives90 over 10 products, all of which could have been derived from tris(l,2,2-trifluoroethyl)amine [(CHF2CHF)3N] the 1,2,2-trifluoroethyl motif is the same as that which occurs in the fluorination of ethyl ethers (Section 25.1.1.3.), and presumably arises via a similar mechanism. 

Four chloro ethers have been fluorinated over cobalt(III) fluoride at 110 150°C. With 2-chloroethyl ethyl ether most of the chlorine is retained114 and the major products (there are... 

ETHYL ETHER (crit.temp. 194) (Tables III to VIII)... 

Several significant pyrrole syntheses involve the formal tricomponent cyclization of type III ace (equation 126). The Hantzsch pyrrole synthesis involves a dicarbonyl compound, an a -halo ketone and ammonia or an amine. The mechanistic pattern is similar to that involved in the Knorr synthesis (Section 3.06.3.4.1). In addition to a-halo ketones and a-haloal-dehydes, compounds such as 1,2-dichloroethyl acetate, 1,2-dibromoethyl acetate and 1,2-dichloroethyl ethyl ether can serve as a -haloaldehyde equivalents (equation 127) (70CJC1689, 70JCS(C)285>. It is believed that the initial step in these reactions is the formation of a stabilized enamine from the amine and the /3 -dicarbonyl compound. A structural ambiguity... 

III 1 % Ethyl ether/petroleum ether Cholesterol esters... 

On the other hand, if the HYD/I+HDO and the HDO/I ratios are very weak for 2,5-dihydrofuran (V), 0.04 and 0.1 respectively, these values increase with ethyl-2-propenyl ether, (III), up to 0.12 and 11. These results are similar too those obtained for 2-cyclohexenol, (VIII), which presents weak hydroge nation and HDO activities (Table 2). 

HAAs HPLC with (i) UV detection at 263 nm (ii) ED at 950 mV (iii) fluori-metric detection at 450 nm (Aex = 360 nm). LiChrosorb RP-Select B column. Mobile phase NH4 (acetate) (pH = 4.5), MeOH, ACN in isocratic and gradient elution. Food flavors, meat extract Cleaning up using the Gross method (94). The spray-dried product was Soxhlet extracted, placed on Kie-selgur, and extracted with ethyl ether. Cleaning up by affinity chromatography on Cu-phthalocya-nine complex. 201... 

Table III. Effect of Repeated Extraction with Ethyl Ether...

The results shown in Table III reveal strong inhibition in the first pair of ethyl ether partitions and in the final water phase. The inhibition was progressively less through the remaining ether partitions, with none in the final pair of ether fractions. This evidence indicates the presence of two inhibitory substances. Organic inhibitor B is not extractable with ether at pH 5 organic inhibitor C is extractable with ether at pH 5. Both are adsorbed by activated charcoal. 

The resulting solution of n-butylmagnesium bromide is cooled to 0° with an ice-salt bath, and a solution of 8.7 ml. (13.7 g. 0.10 mol) of redistilled phosphorus (III) chloride (density, 1.57) in 50 ml. of anhydrous ethyl ether is added dropwise with stirring over a period of about an hour. The mixture is then refluxed by warming for % hour, cooled below 0° in an ice-salt bath (ca. hour minimum) and treated with 250 ml. of an ice-cold aqueous solution containing 50 g. of ammonium chloride. ... 

The degree of substitution (DS) of the EC substrate has a pronounced effect (Table III). At high DS values, conversion of monomer increases from about 70 to the level 80%, but the grafting efficiency decreases at DS=0.60. This may be a blocking effect of the ethyl ether groups and to some extent an effect of increased water solubility of the substrate after grafting. The intermediate DS-level (0.40) is most favorable for grafting. 

The red-sided garter snake pheromone components were isolated by hexane extraction of the skin lipids of sacrificed snakes. Female snakes yielded more total lipid than males (38.4 versus 8.4mg snake-1)80 Initial fractionation on an activity III alumina column gave a fraction (eluted with 98 2, hexanes ethyl ether) that was attractive to courting males. NMR and infrared (IR) spectra of this fraction were suggestive of the presence of methyl ketones, straight chain alkyl lipid subunits, and Z-alkenes. GC—MS analysis, including extensive consideration of the fragmentation of the electron impact MS data, led to the identification of a family of relatively nonvolatile (C29—C37) lipid methyl ketones. Specifically, the individual components of a mixture of saturated and monounsaturated methyl ketones 18—30 were identified. 

A suspension of bromobis[2,3-butanedione dioximato( 1 -)] (4-rerr-butylpyri-dine)cobalt(III) (2.5 g, 5.0 mmole) (see above) in 20 mL of methanol in a 100 mL, three-necked flask is vigorously stirred under an N2 purge for 10 minutes. While it is stirred and purged with N2, solid sodium tetrahydroborate (0.5 g, 13 mmole) is gradually added in about 0.1-g portions. Upon addition of the sodium tetrahydroborate, the solution becomes warm, shows considerable effervescence due to hydrogen evolution, and becomes homogeneous. The development of the dark blue-black color is characteristic of the reduced Co(I) species. Then 2-bromoethyl ethyl ether (0.56 mL, 5.0 mmole) is added and the solution turns red-brown, indicating the presence of the alkylcobalt(III) species. The reaction mixture is then stirred for 15 minutes. To obtain maximum yields, another 0.25 g of solid sodium tetrahydroborate is added, followed by addition of an extra 0.25 mL of 2-bromoethyl ethyl ether. The reaction mixture is stirred for another 10 minutes. Further additions of sodium tetrahydroborate and 2-bromo-... 

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