Estrogen-related receptors

ER Estrogen Receptor, AR Androgen Receptor, GR Glucocorticoid Receptor, TR Thyroid Receptor, RAR Retinoic Acid Receptor, RXR Retinoie X Receptor, PR Progesterone Receptor, VDR Vitamin D Receptor, PPAR Peroxisome Proliferator-Activated Receptor, PXR Pregnane X Receptor, ROR Retinoic Acid-Related Orphan Receptor, NHF-4 Hepatocyte Nuclear Eactor 4, ERR Estrogen-Related Receptor... [Pg.2]

Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, Oakeley EJ, Kralli A (2004) The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1 alpha (PGC-lalpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101(17) 6472-6477. doi 10.1073/ pnas.0308686101... [Pg.456]

The estrogen-related receptors (ERR, a, 3 and d) is structurally most related to the canonical ER and has been shown to modulate estrogen signaling. These observations have heightened interest in ERR as a therapeutic target in both breast and ovarian cancer and in other estrogenopathies. ... [Pg.104]

Stein, R. A., McDonnell, D. P. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr. Relat. Cancer. 2006, J5(Suppl 1), S25-32. [Pg.105]

Coward, P., Lee, D., Hull, M.V. and Lehmann, J.M. (2001) 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor y. Proceedings of the National Academy of Sciences of the United States of America, 98, 8880-8884. [Pg.61]

Luo, J., Sladek, R., Carrier, J., Bader, J., Richard, D. and Giguere, V. (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor a. Molecular and Cellular Biology, 23, 7947-7956. [Pg.61]

Ariazi, E.A., Clark, G.M. and Mertz, J.E. (2002) Estrogen-related receptor a and estrogen-related receptor y associate with... [Pg.172]

Subfamily 3 estrogen receptor homology estrogen receptor (ER) a, p estrogen related receptor (ERR) a, p, y glucocorticoid receptor (GR) mineralocorticoid receptor (MR) progesterone receptor (PR) androgen receptor (AR)... [Pg.368]

Greschik, H., Wurtz, J.M., Sanglier, S., Bourguet, W., van Dorsselaer, A., Moras, D., and Renaud, J.P., Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3, Mol Cell, 9, 303-313,2002. [Pg.153]

Ao A, Wang H, Kamarajugadda S, Lu J. Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors. Proc Natl Acad Sci 2008 105 7821-7826. [Pg.42]

Okada H et al. (2008) Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma. Environ. Health Perspect. 116(l) 32-38. [Pg.31]

Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 1(13), 981-991,2003. [Pg.257]

Estrogen-related receptor alpha Diabetes, obesity (74], osteoporosis 141... [Pg.120]

WiUy PJ, Murray IR, Qian J, Busch BB, Stevens WC Jr, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp DW, Horlick RA, Heymtm RA, Schulman IG (2004) Regulation of PPARy coactivator la (PGC-la)signtiling by tm estrogen-related receptor a (ERRa) ligand. Proc Natl Acad Sci U S A 101 8912-8917... [Pg.416]

Scheme 15.21 shows a novel 3,5-substituted thiazolidine-2,4-dione under development at Janssen as a potent inhibitor of estrogen related receptor 1 (ERR-1) for the treatment of hyperglyeemia. Epoxide opening furnishes the... [Pg.301]

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