Estrogens pathways

Cenotoxic Estrogen Pathway Endogenous and Equine Estrogen Hormone Replacement Therapy... 

The estrogens are a family of hormones synthesized in a variety of tissues. 17P-Estradiol is the primary estrogen of ovarian origin. In some species, estrone, synthesized in numerous tissues, is more abundant. In pregnancy, relatively more estriol is produced, and this comes from the placenta. The general pathway and the subcellular localization of the enzymes involved in the early steps of estradiol synthesis are the same as those involved in androgen biosynthesis. Features unique to the ovary are illustrated in Figure 42-7. 

WANG TTY, SATHYAMOORTHY N, PHANG J M (1996) Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis. 17 271-5. 

Saltiere-Imerly R.B., Young B.J. and Capozza M.A. (1989). Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway. Proc Natl Acad Sci 86, 4766-4770. 

The estrogenic properties of isoflav-3-enes are well known and consequently, several derivatives of these chromene heterocycles have been the target of medicinal chemists. Varma and coworkers uncovered a useful enamine-mediated pathway to this class of compounds [142-144], Now the group has discovered a facile and general method for the MW-expedited synthesis of isoflav-3-enes substituted with basic moieties at the 2-position (Scheme 6.42) [145], These promising results are especially appealing in view of the convergent one-pot approach to 2-substituted isoflav-3-enes... 

Akama, K. T. and McEwen, B. S. Estrogen stimulates post-synaptic density-95 rapid protein synthesis via the Akt/ protein kinase B pathway. /. Neurosci. 23 2333-2339,2003. 

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