Estrogen deficiency symptoms

Estradiol (valerate) Estradiol + norethindronate (acetate) Estradiol (valerate ) + levonorgestrel Hormone-replacement therapy in estrogen-deficiency symptoms and prevention of osteoporosis in postmenopausal women... 

Other symptoms, including mood swings, depression, insomnia, migraine, formication, arthralgia, myalgia, and urinary frequency, are attributed to menopause, but the relationship between these symptoms and estrogen deficiency is controversial. 

It is indicated in vasomotor symptoms in estrogen deficiency and osteoporosis prophylaxis. 

Finally, sex steroids are also implicated in the pathophysiology of depression. Estrogen deficiency states, which occur in the postpartum and postmenopausal periods, are thought to play a role in the etiology of depression in some women. Likewise, severe testosterone deficiency in men is sometimes associated with depressive symptoms. Hormone replacement therapy in hypogonadal men and women may be associated with an improvement in mood and depressive symptoms. 

Estrogens cause abnormalities of tryptophan metabolism that resemble those seen in vitamin Be deficiency, and the vitamin is widely used to treat the side effects of estrogen administration and estrogen-associated symptoms of the premenstrual syndrome, although there is litde evidence of its efficacy. High doses of the vitamin, of the order of 100 times requirements, cause peripheral sensory neuropathy. 

Whittington, R. and Faulds, D. (1994) Hormone replacement therapy I. A pharmacoeconomic appraisal of its therapeutic use in menopausal symptoms and urogenital estrogen deficiency . Pharmacoeconomics. 5, 419 45. Review. Erratum in Pharmacoeconomics (1995), 8, 244. 

The varied clinical uses of estrogens include menstrual disorders, alleviation of menopause, associated symptoms (replacement therapy), osteoporosis, postmenopausal breast cancer and prostatic cancer and hypertrophy, lactation suppression, postcoital contraceptives, oral contraceptives (combined with progestins), estrogen deficiencies unrelated to the menopause, ovarian failure, and hypogenitalism. 

Natural menopause is associated with a rapid decline in circulating estrogen and, apart from the loss of reproductive function, the decline in sex hormones has many imphcations for nomeproductive tissues. Estrogen deficiency in postmenopausal women can lead to unpleasant symptoms such as hot flashes and vaginal diyness, with a long-... 

Menopause is a condition of estrogen deficiency that triggers several symptoms snch as hot flash, anxiety, irritability, and bone loss. Synthetic hormones have been extensively... 

Unkila, M., The use of a lignan for the manufacture of a composition for preventing or alleviating of symptoms relating to estrogen deficiency. World Patent WO 072647 Al,... 

The theoretical starting point is the observation that (particularly after oophorectomy) there are deficiencies of both testosterone and androstenedione (3) and from the observation that estrogens alone do not relieve all menopausal symptoms. While there may well be justification for androgen replacement after oophorectomy, it is not clear that most of the claims made for use of this approach following a natural menopause are sufficiently well founded to justify the risks involved. 

The most frequent and prevalent use of the female hormones is in contraceptive preparations (see Hormonal Contraceptives ). The other primary indications for estrogen and progesterone are replacement of endogenous hormone production and subsequent resolution of symptoms related to hormonal deficiencies. This replacement can be especially important following menopause—that is, when the female reproductive cycle ceases and the associated cyclic production of the ovarian hormones ends. Specific clinical conditions that may be resolved by estrogen and progesterone are listed below. 

Estropipate is indicated in the management of moderate to severe vasomotor symptoms associated with menopause female hypogonadism, female castration, primary ovarian failure, and atrophic conditions caused by deficient endogenous estrogen production prevention and treatment of osteoporosis. 

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