Estrogen conjugated + medroxyprogesterone

Estrogen/ Conjugated + Medroxyprogesterone (Prempro, Premphase) [Estrogen/Progestin Hormones] WARNING ... 

Utian WH, Shoupe D, Backmann G, et al. Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril 2001 75 1065-1079. 

CEE, conjugated equine estrogens MPA, medroxyprogesterone acetate NETA, norethindrone acetate. 

AECAPS/TexCAPS = Air ForceAexas Coronary Atherosclerosis Prevention Study (Downs et ah, 1998) Helsinki = The Helsinki Heart Study (Frick et al., 1 987) LRC-CPPT = The Lipid Research Clinics Coronary Primary Prevention Trial (insull et al., 1984) Oslo = The Oslo Study (Hjermann et ah, 1988) WOSCOPS = The West of Scotland Coronary Prevention Study (Shepherd et al., 1995) ALLHAT = Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial approximately 13-15% of patients had a history of coronary heart disease (CHD) events are CHD events only WHI = Women s Health initiative RRR = relative risk reduction ARR = absolute risk reduction NNT = number needed to treat NA = not available CEE = conjugated equine estrogen MPA = medroxyprogesterone acetate CARDS = Collaborative Atorvastatin Diabetes Study (presented at the 2004 American Diabetes Association meeting). 

Estrogen alone for days 1M 4, followed by estrogen-progestogen on days 15-28. CEE, conjugated equine estrogens MPA, medroxyprogesterone acetate NETA, norethindrone acetate. 

A 52-year-old postmenopausal patient has evidence of low bone mineral density. She and her physician are considering therapy with raloxifene or a combination of conjugated estrogens and medroxyprogesterone acetate. Which of the following patient characteristics is MOST likely to lead them to select raloxifene ... 

Activella—estradiol, norethindrone acetate CombiFhtch—estradiol, norethindrone Femhrt—ethinyl estradiol, norethindrone acetate Ortho-Pretest—estradiol, norgestimate Premephase—conjugated estrogens, medroxyprogesterone acetate... 

Low-dose hormone therapy (conjugated equine estrogen 0.45 mg and medroxyprogesterone acetate 1.5 mg/day) has demonstrated equivalent symptom relief and bone density preservation without an increase in endometrial hyperplasia. Whether such lower doses will be safer (cause less venous thromboembolism and breast cancer) remains to be seen. 

Premphase One 0.625 mg conjugated estrogens tablet once daily on days 1 through 14 and one 0.625 mg conjugated estrogen/5 mg medroxyprogesterone tablet taken once daily on days 15 through 28. 

Estrogen/progestogen combinations, oral conjugated estrogens/ medroxyprogesterone ethinyl estradiol/norethindrone acetate mestranol/norethindrone... 

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