Estimation method, choosing strategy

The estimate of the fill time shows that a more detailed study of injection strategy and process parameters is necessary because it is difficult to reach an acceptable production economy with a fill time of about 1 h. An obvious action would be to choose a more efficient resin distribution method than a one-point inlet (e.g., peripheral injection or a multipoint injection). In addition, it would be worthwhile to try to lower the viscosity and increase the pressure. 

If the sample is representative, then the second consideration is how artefacts of randomly choosing the samples lead to random variation in the estimate of statistics of interest, such as the mean or standard deviation of sample distribution of interindividual variability. While it is often assumed that a small sample of data is not or could not be representative, this is a common misconception. The issue of representativeness is one of study design and sampling strategy. If one has a representative sample, even if very small, then conventional statistical methods can be used to make inferences regarding sampling distributions of statistics, such as... 

The main problem with the DFT methods is the lack of a recipe to find the appropriate forms of the <, and functionals. On the other hand, the main problem with the ab initio methods is the computation of the electronic correlation effects neglected in the HF approximation. All the pos-HF methods shown in Table VILl exhibit a rather steep increase in computational cost as the size of the basis set increases. In order to obtain a good estimate of the electronic correlation effects without making use of very large basis sets, calculations from different levels of theory can be combined. Examples of such strategy are the complete basis set (CBS) family of methods, developed by Petersson et al. [21] and the Gaussian (Gn) methods, developed by Pople and co-workers [22], By choosing the appropriate level of theory and size of the basis set to be used at each different step of the calculation, the CBS and Gn methods can produce total... 

Choose the thermodynamic methods for property and phase equilibrium estimations. Consider possible heat recovery and heat integration strategies for all the processes analyzed. Obtain a converged solution using a simulator for the mass and energy balances. 

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