Metabolic engineering Escherichia coli

Pitera, D.J., Paddon, C.J., Newman, J.D. and Keasling, J.D. (2007) Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metabolic Engineering, 9, 193-207. 

Schmid, J. W., Mauch, K., Reuss, M., GiUes, E. D. and Kremling, A. (2004). Metabolic design based on a coupled gene expression-metabolic network model of tryptophan production in Escherichia coli. Metabolic Engineering, 6(4), 364-311. 

Alper, H., Jin, Y. S., Moxley, J. R, Stephanopoulos, G. (2005). Identifying gene targets for the metaboiic engineering of lycopene biosynthesis in Escherichia coli. Metabolic Engineering, 7,155-164. 

Gonzalez, R., Murarka, A., Dharmadi, Y, et al., 2008. A new model for the anaerobic fermentation of glycerol in enteric bacteria trunk and auxiliary pathways in Escherichia coli. Metabolic Engineering 10,234-245. 

Jrmg, W, Kang, J., Chu, H., Choi, I., Cho, K., 2014. Elevated production of 3-hydroxy propionic acid by metabolic engineering of the glycerol metabolism in Escherichia coli. Metabolic Engineering 23,116-122. 

Farmer, W.R. and Liao, J.C., Improving lycopene production in Escherichia coli by engineering metabolic control, Nat. Biotechnol. 18, 533, 2000. 

Bernstein HC, Paulson SD, Carlson RP (2012) Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity. J Biotechnol 157 159-166 Blank LM, Kuepfer L (2010) Metabolic flux distributions genetic information, computational predictions, and experimental validation. Appl Microbiol Biotechnol 86 1243-1255 Bloom AJ, Chapin FS, Mooney HA (1985) Resource Umitation in plants - an economic analogy. Annu Rev Ecol Syst 16 363-392... 

FIGURE 9.5 Aerobic metabolism of an Escherichia coli strain engineered to produce succinic acid with a partial tricarboxylic acid cycle (Lin et al., 2005b). 

Gallagher, C.E., Cervantes-Cervantes, M., and Wurtzel, E.T., Surrogate biochemistry use of Escherichia coli to identify plant cDNAs that impact metabolic engineering of carotenoid accumulation, AppZ. Microbiol. Biotechnol. 60, 713, 2003. 

Wang, C., Oh, M.K., and Liao, J.C., Directed evolntion of metabolically engineered Escherichia coli for carotenoid production, Biotechnol. Progr. 16, 922, 2000. 

Matthews, P.D. and Wurtzel, E.T., Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase, Appl. Microbiol. Biotechnol. 53, 396, 2000. 

Watts, K. T., R C. Lee et al. (2006). Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli. BMC Biotechnol. 6 22. 

Kennedy, J., Murli, S. and Kealey, J.T. (2003) 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. Biochemistry, 42, 14342. 

Kim, S.-W. and Keasling, J.D. (2001) Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnology and Bioengineering, 12, 408-415. 

Murli, S., Kennedy, J., Dayem, L.C. et al. (2003) Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. Journal of Industrial Microbiology and Biotechnology, 30 500—509. 

ERYTHROMYCIN D Staunton 1997 Wu 2000) high-performance production of 6-deoxyerythronolide has been achieved by fermentation of a metabolically engineered strain of Escherichia coli Pfeifer 2001 methvmvcins. calicheamicins. and pikromvcins METHYMYCIN-CALICHEAMICIN-class and pikromycin-calicheamicin-class Micromonospora echnospora CalH - Streptomyces venezuelae mutant Zhao 1999). 

Leonard E, Lim K-H, Saw P-N, Koffas MAG. 2007a. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. App. Env Microb 73 3877-3886. 

A. A. Aristidou, G. N. Bennett, and K. Y. San, Metabolic engineering of Escherichia coli to enhance recombinant protein production through acetate reduction, Biotechnol. Progr. 1995, 375-478. 

Biosynthesis of Poly (3-hydroxy butyrate-co-3-hydroxyalkanoates) by Metabolically Engineered Escherichia coli Strains... 

Biosynthesis of (f )-3-Hydroxyalkanoic Acids by Metabolically Engineered Escherichia coli... 

Recombinant Escherichia coli strains harboring the heterologous PHA biosynthesis genes have been shown to be suitable for the high-level production of PHAs. In addition, several engineered metabolic pathways for the synthesis of various RHAs have recently been established in recombinant E. coli (16-18). 

Dharmadi, Y., Murarka, A. and Gonzalez, R. 2006. Anaerobic Fermentation of Glycerol by Escherichia Coli A New Platform for Metabolic Engineering. Biotechnol. Bioeng., 94, 821— 829. 

J. D. Keasling, S. J. Van Dien and J. Pramanik (1998). Engineering polyphosphate metabolism in Escherichia coli - implication for bioremediation of inorganic contaminants. Biotechnol. Bioeng., 58, 231-239. 

Integration of Systems Biology with Bioprocess Engineering L-Threonine Production by Systems Metabolic Engineering of Escherichia Coli... 

Lee KH, Park JH, Kim TY et al (2007) Systems metabolic engineering of Escherichia coli for L-threonine production. Mol Syst Biol 3 149... 

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