Metabolic engineering strain

Figure 12.1 The biosynthesis of 6dEB catalyzed by DEBS [58]. (From B.A. Pfeifer, S.J. Admiraal, H. Gramajo et al. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 291 1790-1792. Washington, DC AAAS. 2001 AAAS. Reprinted with permission from AAAS.)...

ERYTHROMYCIN D Staunton 1997 Wu 2000) high-performance production of 6-deoxyerythronolide has been achieved by fermentation of a metabolically engineered strain of Escherichia coli Pfeifer 2001 methvmvcins. calicheamicins. and pikromvcins METHYMYCIN-CALICHEAMICIN-class and pikromycin-calicheamicin-class Micromonospora echnospora CalH - Streptomyces venezuelae mutant Zhao 1999). 

Blaine A. Pfeifer, Suzanne J. Admu aal, Hugo Gramajo, David E. Cane, Chaitan Khosla, Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli, Science, 291 (2001), 1790-1792. 

Vemuri GN, Eiteman MA, Altman E. (2002). Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli. Appl Environ Microbiol, 68, 1715-1727. 

Pfeifer, B.A. et al.. Biosynthesis of complex polyketides in a metabolically engineered strain of E. 

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