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Erythroidines

Erythroidine behaves as a lactone and when one of its salts with an alkali or alkaline earth metal is catalytically hydrogenated under pressure, a mixture of dihydro-j3-erythroidines, with two tetrahydro- compounds is produced, from which dihydro- -erythroidine can be isolated as the hydrobromide. The dihydro- base has m.p. 85-6° (dec.), + 102-5° and... [Pg.387]

As -erythroidine and its hydrides appear to be important curarising agents in the erythrina series it is convenient to tabulate at this stage the threshold curarising potencies of these alkaloids and to add for comparison the curarising potencies of the other free erythrina alkaloids. Similar tables are given later for the liberated and combined (p. 390) alkaloids. [Pg.387]

In view of the fact that the conversion of tertiary into quaternary base other hand, hydrogenation in this series ma have 110 effect on activity (cf. erythraline and its dihydro-derivative ery thramine) or may enhance it (cf. -erythroidine and its dihydride) or mai diminish it (cf. erythramine and its dihydride). [Pg.388]

It has long been known that quaternary ammonium salts can exert a curare-like action, and in recent years much attention has been given to the synthesis and pharmacological testing of such products work on this subject up to 1936 has been reviewed by Ing, and more recently a theoretical discussion of the relationship between structure and action in drugs of this type has been provided by Holmes, Jenden and Taylor.Chase, Lehmann and Yonkmann have compared the action of quaternary salts of quinine with that of -erythroidine hydrochloride and of dihydro- -erythroidine hydrobromide. Quinine ethochloride shows marked curariform action of short duration. ... [Pg.392]

Dihydrocinchonicine, 452 Dihydrocinchonidine, 429 Dihydrocinchonine, 428 Dihydrocinchotoxine, 452 Dihydrocodeine, 260 Dihydrocodeinone, 245, 260, 270 Dihydroeodeinone oxime, reactions, 244 Dihydromeiacodeinone, 249 Dihydrocryptopine and isodihydrocryptopine, 296 Dihydrocupreicine, 452 Dihydrocupreidine, 431 Dihydrocupreine, 431 Dihydrodeoxymorphines, 254, 260-2 Dihydroecgonidine, 99 Dihydro- -erythroidines, 387... [Pg.790]

Figure 6.2 Diagrammatic representation of a cholinergic synapse. Some 80% of neuronal acetylcholine (ACh) is found in the nerve terminal or synaptosome and the remainder in the cell body or axon. Within the synaptosome it is almost equally divided between two pools, as shown. ACh is synthesised from choline, which has been taken up into the nerve terminal, and to which it is broken down again, after release, by acetylcholinesterase. Postsynaptically the nicotinic receptor is directly linked to the opening of Na+ channels and can be blocked by compounds like dihydro-jS-erythroidine (DH/IE). Muscarinic receptors appear to inhibit K+ efflux to increase cell activity. For full details see text... Figure 6.2 Diagrammatic representation of a cholinergic synapse. Some 80% of neuronal acetylcholine (ACh) is found in the nerve terminal or synaptosome and the remainder in the cell body or axon. Within the synaptosome it is almost equally divided between two pools, as shown. ACh is synthesised from choline, which has been taken up into the nerve terminal, and to which it is broken down again, after release, by acetylcholinesterase. Postsynaptically the nicotinic receptor is directly linked to the opening of Na+ channels and can be blocked by compounds like dihydro-jS-erythroidine (DH/IE). Muscarinic receptors appear to inhibit K+ efflux to increase cell activity. For full details see text...
Drugs that block the nicotinic receptors on autonomic ganglia, such as hexamethonium, probably do so by actually blocking the Na+ ion channel rather than the receptor. Generally these receptors appear to resemble the central ones more than those at the neuromuscular junction and dihydro-jS-erythroidine is one drug that it is an effective antagonist in both ganglia and the CNS. [Pg.130]

Stolerman IP, Chandler CJ, Garcha HS, Newton JM (1997) Selective antagonism of behavioural effects of nicotine by dihydro-/i-erythroidine in rats. Psychopharmacology 129 390-397... [Pg.331]

Wiley JL, LaVecchia KL, Martin BR, Damaj MI (2002) Nicotine-like discriminative stimulus effects of bupropion in rats. Exp Clin Psychopharmacol 10 129-135 Williams M, Robinson JL (1984) Binding of the nicotinic cholinergic antagonist, dihydro-beta-erythroidine, to rat brain tissue. J Neurosci 4 2906-2911 Witkin JM, Dykstra LA, Carter RB (1982) Acute tolerance to the discriminative stimulus properties of morphine. Pharmacol Biochem Behav 17 223-228 Wooters TE, Bardo MT (2007) The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats. Behav Pharmacol 18 601-608 Wright JM Jr, Vann RE, Gamage TE, Damaj MI, WUey JL (2006) Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats. Pharmacol Biochem Behav 85 507-513... [Pg.332]

Malin DH, Lake JR, Upchurch TP, Shenoi M, Rajan N, Schweinle WE (1998a) Nicotine abstinence syndrome precipitated by the competitive nicotinic antagnist dihydro-beta-erythroidine. Pharmacol Biochem Behav 60 609-613... [Pg.431]

Soto-Hernandez, M. and Jackson, A. H. 1993. Studies of alkaloids in foliage of Erythrinia berteroana and E. poeppigiana detection of 3-erythroidine in goats milk. Phytochemical Analysis, 4 97-99. [Pg.246]

Motoneuron-Renshaw cell synapse Nicotinic nicotine Dihydro-B-erythroidine, a-bungarotoxin Excitatory t cation conductance... [Pg.459]

See other pages where Erythroidines is mentioned: [Pg.315]    [Pg.519]    [Pg.521]    [Pg.271]    [Pg.386]    [Pg.387]    [Pg.387]    [Pg.387]    [Pg.387]    [Pg.388]    [Pg.391]    [Pg.792]    [Pg.64]    [Pg.123]    [Pg.132]    [Pg.25]    [Pg.44]    [Pg.139]    [Pg.307]    [Pg.312]    [Pg.366]    [Pg.406]    [Pg.33]    [Pg.39]    [Pg.39]    [Pg.58]    [Pg.290]    [Pg.290]    [Pg.293]    [Pg.301]    [Pg.301]    [Pg.181]    [Pg.562]    [Pg.208]    [Pg.208]    [Pg.529]    [Pg.575]   
See also in sourсe #XX -- [ Pg.483 , Pg.497 ]



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A- and 3-Erythroidine

A-Erythroidine

Dihydro-/3-erythroidine

Dihydro-/3-erythroidine nicotinic receptor antagonist

Dihydro-P-erythroidine

Dihydro-beta-erythroidine

Erythrina alkaloids 3-Erythroidine

Erythroidine

Erythroidine

Erythroidine alkaloids

Erythroidine alkaloids synthesis

Erythroidine biosynthesis

J8-Erythroidine

P-Erythroidine

Tetrahydro-erythroidine

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