Ergometrine

Ergometrine and Ergometrinine, Ci9H230 3. The isolation of these alkaloids has been referred to already (p. 517). A method for the preparation of ergometrine has been described by Dudley, and the following characters are mainly those given by that author —... 

Ergometrine crystallises, with solvent, from benzene in needles or from methyl ethyl ketone in prisms both forms have m.p. 162-3° (dec.). From ethyl acetate it crystallises at — 4° in thin, solvent-free plates, m.p. 160-1° (dec.), and at atmospheric temperature on concentration in vacuo in diamond-shaped plates, B.0-5EtAc, m.p. 130-2° (dec.), from which the combined solvent is not removed at 100° in vacuo. By crystallisation from acetone, Grant and Smith obtained a second form in long needles, m.p. 212° (dec.), which appears to be the more stable, since the form, m.p. 162-3°, tends to pass into it on keeping. Ergometrine has [o]d — 44° (CHCI3) - - 42-2° or + 62-6° (c = 1-7, EtOH) or... 

These hydrazides on treatment with nitrous acid are converted into azides, which with appropriate amino-alcohols, furnish ergometrine and its isomerides and analogues. The four pairs of stereoisomeric ergo-metrines and ergometrinines in the following list have been prepared in this way with l-( -(-)-)S-aminopropyl alcohol or its d-( —)-isomeride. 

The propanolamine obtained by hydrolysis of ergometrine and ergometrinine is dextrorotatory, but belongs to the I- series and appears to be fully described as Z-(-)-)- 3-aminopropyl alcohol. 

Of the typical ergot alkaloids, six pairs f table, p. 526) are now known. The first five pairs are more complex in structure than the sixth pair, ergometrine and eigometrinine. 

Brown and Dale have shown that ergometrine (a) produces central... 

C3H9NO 2749-11-3) see Ergometrine Levofloxacin L-alanyl-D-isoglutaminyl-7V -(benzyloxycarbonyl)-L-lysine benzyl ester... 

Their reaction was tested on the individual components of the test mixture indole, ergotamine tartrate, ergotaminine and ergobasine [ergometrine) [3]. The results obtained were as follows ... 

Ergocomine lb 243 Ergocristine lb 245,348 Ergocryptine lb 379 Ergoline carboxylic acids lb 243 Ergometrine lb 243,252,440,444 Ergosterol la 351... 

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