Lysin 5 -2-Benzyl

C3H9NO 2749-11-3) see Ergometrine Levofloxacin L-alanyl-D-isoglutaminyl-7V -(benzyloxycarbonyl)-L-lysine benzyl ester... 

N -(benzyloxycarbonyl)- ethyl L-lysine benzyl ester chloroformote... 

L-olonyl-D isoglutominyl-N -(benzyl-oxycarbonyl)-L-lysine benzyl ester (III)... 

The PEAs reported in this work were prepared in a simple way by solution or interfacial polycondensation, where di-p-toluenesulfonic acid salts of bis-(a-amino acid)-a,co-alkylene diesters react with chlorides of dicarboxylic acids (interfacial polycondensation) or their active diesters (Active Polycondensation, APC). The APC method involves the condensation of two partners (I) bis-electrophilic, activated dicarboxylic acids, and (II) bis-nucleophilic, acid salts of bis-(a-amino acid)-a,(0-alkylene diesters in combination with di-p-toluenesulfonic acid salts of L-lysine benzyl ester. This reaction proceeds under mild conditions in common organic solvents and leads to polymer of high molecular weight (up to 300 KDa). A detailed review of the APC method has been recently summarized by Katsarava (7). 

All starting materials and solvents were obtained from commercial sources (Sigma-Aldrich, Fisher Scientific Int.). Active di-esters (of Formula I) di-p-nitrophenyl adipate, I.l (1), di-p-nitrophenyl sebacate, 1.2 (1), di-p-nitrophenyl fumarate, 1.3 (10), and bis-nucleophilic monomers (of general Formula II) di-p-toluenesulfonic acid salts of bis(a-aminoacyl)-a,(o-alkylene diesters (1, 2), and di-p-toluenesulfonic acid salt of L-lysine benzyl ester (11,12) were prepared as described previously. 

Recently, Gallot et al. succeeded in preparing well characterized block copolymers by polymerization of 7-benzyl-L-glutamate NCA and e-carbobenzoxyl-L-lysine NCA with a primary amine ended polystyrene or polybutadiene in dioxane or ben-... 

Nonideal interactions can be also be characterized using small-molecule probes.7 Ideally, these probes should elute at Vu. Cation-exchange interactions can be detected by excessive retention of arginine or lysine.8 Ion-exclusion effects can be characterized by early elution of citrate or glutamic acid. Hydrophobic interactions can be detected by late elution of phenylethyl alcohol or benzyl alcohol.8... 

The variety of educts and products of the higher MCRs is illustrated here. Product 72 (Scheme 1.18) is formed from the five functional groups of lysine, benzaldehyde, and tert-butylisocyanide. The synthesis of 73 is achieved with hydrazine, furanaldehyde, malonic acid, and the isocyano methylester of acetic acid, compound 74 results from the reaction of benzylamine, 5-methyl-2-furanaldehyde, maleic acid mono-ethylester, and benzylisocyanide. ° Zhu et al. prepared a variety of related products, such as, 75, from (9-amino-methyl cinnamate, heptanal, and a-isocyano a-benzyl acetamides. 

Fig. 4. Schematic representation of the structure of polymer-heme complexes the ferriheme complex with poly(4-vinylpyridine) (a), poly(L-lysine) (b), (c), or poly(7-benzyl-L-glutamate) with a pendant imidazole (d)...

The search for other amino acid-based catalysts for asymmetric hydrocyanation identified the imidazolidinedione (hydantoin) 3 [49] and the e-caprolactam 4 [21]. Ten different substituents on the imide nitrogen atom of 3 were examined in the preparation, from 3-phenoxybenzaldehyde, of (S)-2-hydroxy-2-(3-phenoxy-phenyl)acetonitrile, an important building block for optically active pyrethroid insecticides. The N-benzyl imide 3 finally proved best, affording the desired cyanohydrin almost quantitatively, albeit with only 37% enantiomeric excess [49]. Interestingly, the catalyst 3 is active only when dissolved homogeneously in the reaction medium (as opposed to the heterogeneous catalyst 1) [49]. With the lysine derivative 4 the cyanohydrin of cyclohexane carbaldehyde was obtained with an enantiomeric excess of 65% by use of acetone cyanohydrin as the cyanide source [21]. 

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