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ERBB2 breast tumors

Zsebik B, Citri A, Isola J et al (2006) Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor ceU Une JIMT-1. Immunol Lett 104 146-155... [Pg.177]

ERBB2 amplification 23 Breast tumor versus bone matastasis 50% (55)... [Pg.97]

ERBB2 amplification 60 Breast tumor versus other metastatic sites 98% (56)... [Pg.97]

Holbro T, Beerli RR, Maurer F, et al. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Nail Acad Sci USA 2003, 100, 8933-8938. [Pg.161]

Mosley ID, Poirier IT, Seachrist DD, Landis MD, Keri RA. Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer. Mol Cancer Ther 2007 6 2188-2197. [Pg.556]

Zaretsky, J. Z., Weiss, M., Tsarfaty, I., Hareuveni, M., Wreschner, D. H., and Keydar, I., 1990, Expression of genes coding for Ps2, C-Erbb2, estrogen receptor and the H23 breast tumor-associated antigen. A comparative analysis in breast cancer, FEBS Lett. 265 46-50. [Pg.196]

Azemar M, Djahansouzi S. Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2. Breast Cancer Res Treat 2003 82 155-64. [Pg.663]

Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, et al. 2002. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2 127-137. [Pg.259]

Target Validation. Several approaches, including those that involve the use of arrays, can be taken to validate short-listed therapeutic candidates. Genes whose transcript profiles suggest additional analysis can be profiled using TMAs in tens to hundreds of tissues by immunohistochemistry [142]. TMAs can be used to identify heterogeneities between primary tumors and their metastases, as demonstrated in the analyses of erbB2 in primary and metastatic breast cancers... [Pg.652]


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See also in sourсe #XX -- [ Pg.803 ]




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Breast tumors

ErbB2

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