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ErbB2

Trastuzumab (Herceptin) Humanized antibody, IgGi ErbB2/Her-2 Receptor down-regulation Breast cancer... [Pg.1255]

Lapatinib (Tykerb) TKI EGFR, ErbB2/Her-2, ErbB4 Inhibition of kinase activity - ATP-competitive Breast cancer... [Pg.1255]

Epidermal Growth Factor (EGF) Receptor Family Epidermal Growth Factor Receptor 2 (ErbB2) Epidural (Space)... [Pg.1491]

Szabo, A., Horvath, G., Szollosi, J. and Nagy, P. (2008). Quantitative characterization of the large-scale association of ErbBl and ErbB2 by flow cytometric homo-FRET measurements. Biophys. J. 95, 2086-96. [Pg.519]

Figure 20.11 Coverage of protein ErbB2 by shotgun proteomic discovery of sample ... Figure 20.11 Coverage of protein ErbB2 by shotgun proteomic discovery of sample ...
Figure 20.11 Coverage of protein ErbB2 by shotgun proteomic discovery of sample fixed for various times, including fresh. The color gradient represents the increasing abundance of the peptides. All were identified at an FDR <1%. Reproduced with permission from Reference 20. Figure 20.11 Coverage of protein ErbB2 by shotgun proteomic discovery of sample fixed for various times, including fresh. The color gradient represents the increasing abundance of the peptides. All were identified at an FDR <1%. Reproduced with permission from Reference 20.
Neuregulins [GGF, ARIA, SMDF, etc.) ErbB2, ErbB3, ErbB4... [Pg.473]

ErbB2 receptor antibody Herceptin Genentech/ Roche 2014 2014... [Pg.354]

Figure 4 Design of a chemically defined diepitope liposomal anticancer vaccine. Small unilamellar liposomes (PC/PG/Chol 75/20/50 molar ratio diameter 65nm) containing 5mol% of the synthetic thiol-reactive lipopeptide adjuvant anchor Pam3CSS-Mal were reacted, at 25°C and pH 6.5, with equimolar quantities of the peptides ErbB2 (p63-71), derivatized with a CG linker at its N-terminus, and HA307-319, derivatized with a C-linker at its C-terminus. Abbreviations PC, phosphatidylcholine PE, phosphatidylethanolamine SUV, small unilamellar vesicles. Source From Refs. 11, 74. Figure 4 Design of a chemically defined diepitope liposomal anticancer vaccine. Small unilamellar liposomes (PC/PG/Chol 75/20/50 molar ratio diameter 65nm) containing 5mol% of the synthetic thiol-reactive lipopeptide adjuvant anchor Pam3CSS-Mal were reacted, at 25°C and pH 6.5, with equimolar quantities of the peptides ErbB2 (p63-71), derivatized with a CG linker at its N-terminus, and HA307-319, derivatized with a C-linker at its C-terminus. Abbreviations PC, phosphatidylcholine PE, phosphatidylethanolamine SUV, small unilamellar vesicles. Source From Refs. 11, 74.
Roth A, et al. Induction of effective and antigen-specific antitumor immunity by a liposomal ErbB2/HER2 peptide-based vaccination construct. Br J Cancer. In press. [Pg.129]

Drummond DC, Marx C, Guo Z, et al. Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes. Clin Cancer Res 2005 11 3392-3401. Mamot C, Drummond Dc, Noble CO, et al. Epledermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugsin vivo. Cancer Res 2005 65 1631-1638. [Pg.167]

Garratt AN, Ozcelik C, Birchmeier C. ErbB2 pathways in heart and neural diseases. Trends Cardi-ovasc Med 2003 13 80-6. [Pg.80]

Scott, G.K,Marden, C.,Xu, F., Kirk, L. and Benz, C.C. (2002) Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. Molecular Cancer Therapeutics,... [Pg.135]

Miller, P., R. C. Schnur, E. Barbacci, M. P. Moyer, and J. D. Moyer. Binding of benzoquinoid ansamycins to plOO correlates with their ability to deplete the erbB2 gene product pl85. Bioche Biophys Res Commun. 201 1313-1319.1994b. [Pg.134]

Xu, W., E. Mimnaugh, M. F. Rosser, C. Nicchitta, M. Marcu, Y. Yarden, and L. Neckers. Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by chaperone protein Hsp90. J Biol Chem. 276 3702-3708.2001. [Pg.139]

Lapatinib Breast EGFR/erbB2 kinase inhibitor 2... [Pg.14]

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