EPTC, methylation

Methyl isocyanate, see Carbaryl, Propoxur Methyl isothiocyanate, see Dazomet Methyl mercaptan, see EPTC. Phorate Methyl(methylaminomethyl)dithiocarbamic acid, see Dazomet... 

The deamination of xenobiotic cysteine conjugates can lead to thlo-acetlc acid conjugates, as observed with PCNB In peanut (100). or thlo-lactlc acid conjugates, as observed with EPTC In corn and cotton (106) or PCNB In peanut (WO). Cysteine conjugates can also undergo 8-lyase cleavage to thioalcohols, as observed with PCNB In peanut (WO). The thioalcohols can be methylated by an S-adenosyl-methlonlne methyltransferase system, as demonstrated with an In vitro enzyme system derived from onion root (J01 ). Pentachloro-... 

On the basis of the metabolic products identified and their relative amounts formed during incubation, a degradative pathway involving hydroxylation and sulfoxidation mechanisms is proposed (Figure 7). EPTC is first hydroxylated at the a-propyl carbon to form a-hydroxy-propyl EPTC. This compound is unstable and breaks down to form N-depropyl EPTC and propionaldehyde. The N-depropyl EPTC is further metabolized to s-ethyl formic acid and propylamine. The s-ethylcarboxylic acid is then demethylated to s-methyl formic acid. This product is hypothesized to degrade to form C02 and methyl mercaptan. 

Soil disinfestation with methyl bromide, vapam, or by solarization controlled degradation of certain pesticides such as EPTC to various degrees (13). Apparently some of the degraders were not affected by these biocides, a fact that was reflected by partial reduction in degradation of EPTC, when compared with the stronger inhibitory effect in sterile soil. 

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