Methyl isothiocyanate

E. A. Hogendoorn, C. Verscliraagen, U. A. Th Brinkman and van P. Zoonen Coupled column liquid chr omatography for the tr ace determination of polar pesticides in water using dhect large-volume injection method development strategy applied to methyl isothiocyanate , Awn/. Chim. Acm 268 205-215 (1992). 

The use of UV adsorption enhancers as reagents that introduce a UV chromaphore into a molecule that is transparent in the UV wavelength range has already been briefly discussed. The two most common reagents are the phenyl and methyl isothiocyanates. These reagents react with amino acids to form thiodantoins. 

Most 1,3-diazepine syntheses employ the insertion of a single carbon fragment between the two nitrogen atoms. This is further exemplified by the use of tosyl isocyanate and methyl isothiocyanate in the preparation of the bicyclic imidazo[4,5-e][l,3]diazepines 46 and the imidazo[4,5-rf][l,3]diazepines 47 respectively <96JHC855, 96JCS(P1)2257>. 

CjHjNS Methyl isothiocyanate CgHjCI 3-Chloro-1-propyne... 

Percentage difference in trapping efficiency relative to the 1 p.g m result. MITC = methyl isothiocyanate. 

CDPR, Air Monitoring for Methyl Isothiocyanate During a Sprinkler Application of Metam-Sodium, Report EH 94-02, California Department of Pesticide Regulation, Sacramento, CA (1994). 

A process research investigation on p38 MAP kinase inhibitors examined the synthesis (on 7 mol scale) of a group of closely related pyrimidinones such as 37, by condensation of a number of arylacetic esters with 4-cyanopyridine and methyl isothiocyanate. Other nitriles were also examined but were much less successful than 4-cyanopyridine 3-cyanopyridine gave a much lower yield and both benzonitrile and 2-cyanopyridine failed completely <06T11714>. 

Similarly, the reaction of cyclic nitrones 187 with methyl isothiocyanate gives tetrahydroimidazo[l,5- ][l,2,4]oxa-diazol-2(l//)-thiones 129 (Equation 81) <2003PS(178)881, 2004MI7>. 

Contrasting with the reported formation of fused [l,3,4]thiadiazole rings in the course of the reaction of 3-substituted-4-amino-5-thio-47/-[l,2,4]triazoles 83 with various isothiocyanates (cf. Section 11.07.8.3, Table 3), the reactions with methyl isothiocyanate and with phenylisocyanate afford 3,7-disubstituted-6,7-dihydro-57/-[l,2,4]triazolo[4,3-f] [l,2,4]triazole-6-thiones 110 and -triazole-6-ones 111, respectively (Equation 29) <1986MI607, 1992IJB167>.The same reaction of 4-amino-l-methyl-3,5-bis(methylthio)[l,2,4]triazolium iodide 112 with aryl isothiocyanates yields the mesoionic compounds 113 (Equation 30) <1984TL5427, 1986T2121>. 

These authors also demonstrated that the outcome of analogous additions of lithiated alkoxyallenes 120 to isothiocyanates is highly dependent on the nature of the alkyl group in the isothiocyanates as depicted in Schemes 8.34and 8.35 [88, 91]. Whereas methyl isothiocyanate 134 leads to pyrrole derivative 135, the correspond-... 

A study was made of RP-HPLC with constant-potential (1.2 V vs SCE) and pulsed-potential amperometric detection using platinum or gold electrodes, of the derivatives of the common amino acids, obtained from phenyl and methyl isothiocyanates. All the thiohydantoins (98) were oxidized at both electrodes LOD was less than 0.2 pM for lysine and glycine, for 50 pL injection268. 

Methyl isocyanate, see Carbaryl, Propoxur Methyl isothiocyanate, see Dazomet Methyl mercaptan, see EPTC. Phorate Methyl(methylaminomethyl)dithiocarbamic acid, see Dazomet... 

Soil. Soil metabolites include formaldehyde, hydrogen sulfide, methylamine, and methyl(methylaminomethyl)dithiocarbamic acid (Hartley and Kidd, 1987), the latter decomposing to methyl isothiocyanate (Ashton and Monaco, 1991 Hartley and Kidd, 1987 Cremlyn, 1991). The rate of decomposition is dependent upon the soil type, temperature, and humidity (Cremlyn, 1991). 

Aqueous solutions of methyl isothiocyanate are slowly oxidized in air to give 2,4-dimethyl-1,2,4-thiadiazoline-3,5-thione (71) <82AHC(32)285>. When mixtures of alkylisothiocyanates and alkyl-isocyanates are chlorinated, 3-oxathiadiazolium salts (198) are formed via an intermediate iminochloromethylsulfenyl chloride (199). Hydrolysis of these salts yields 2,4-dialkyl-1,2,4-thia-diazolidin-3,5-diones (200) (Scheme 45) <80USP4183816>. 

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